myomegalin Activators
The chemicals Rolipram, Forskolin, IBMX, and Cilostazol directly influence the levels of cAMP in the cell. They either inhibit the phosphodiesterases like PDE4 and PDE3, which are responsible for breaking down cAMP (Rolipram, IBMX, Cilostazol), or directly activate the enzyme adenylate cyclase that generates cAMP from ATP (Forskolin). The increased intracellular cAMP levels activate Protein Kinase A (PKA), which can phosphorylate and thereby enhance the functional activity of Myomegalin. Myomegalin is a centrosomal protein that can associate with AKAP450, a PKA-anchoring protein, implying a possible direct interaction of PKA and Myomegalin. Thus, the functional activity of Myomegalin can be enhanced by phosphorylation through PKA.
Additionally, compounds like Epinephrine, Dopamine, Isoproterenol, Glucagon,Histamine, Calcitonin, Oxotremorine-M, and PGE2 can also increase the intracellular cAMP levels, but they do so indirectly through G protein-coupled receptors (GPCRs). These chemicals are either hormones (Epinephrine, Glucagon, Calcitonin), neurotransmitters (Dopamine, Histamine), or receptor-specific agonists (Isoproterenol for beta-adrenergic receptors, Oxotremorine-M for muscarinic acetylcholine receptors, PGE2 for prostaglandin receptors). Upon binding to their respective receptors, they activate the enzyme adenylate cyclase, which then increases the production of cAMP. As described earlier, the elevated cAMP levels activate PKA, which can phosphorylate and enhance the functional activity of Myomegalin. In conclusion, the activation of Myomegalin can be achieved indirectly through various pathways, all converging at the level of cAMP and its downstream effector, PKA.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4). By inhibiting PDE4, Rolipram increases the levels of cAMP within the cell. This can lead to the activation of Protein Kinase A (PKA), which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a plant-derived compound that directly activates adenylate cyclase, an enzyme that generates cAMP from ATP. Higher cAMP levels activate PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of PDE, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a PDE3 inhibitor, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a hormone and neurotransmitter that can activate adenylate cyclase via beta-adrenergic receptors, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that can activate adenylate cyclase via D1-like receptors, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that activates adenylate cyclase, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Glucagon is a peptide hormone that activates adenylate cyclase via glucagon receptors, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, when bound to H2 receptors, activates adenylate cyclase, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||
Calcitonin, Salmon | 47931-85-1 | sc-201167 sc-201167A | 1 mg 5 mg | $151.00 $613.00 | 1 | |
Calcitonin is a hormone that activates adenylate cyclase via calcitonin receptors, leading to increased cAMP levels. This, in turn, activates PKA, which can phosphorylate and enhance the functional activity of Myomegalin. | ||||||