MYH2 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
(S)-(-)-Blebbistatin is a selective inhibitor of non-muscle myosin II, characterized by its unique ability to disrupt myosin-actin interactions. This compound exhibits distinct binding dynamics, favoring the inactive state of myosin, which alters the kinetics of muscle contraction and cellular motility. Its stereochemistry plays a crucial role in modulating the conformational changes necessary for myosin function, thereby influencing cellular processes and mechanical properties at the molecular level. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 inhibits myosin light chain kinase (MLCK), which plays a role in phosphorylation of myosin light chain, a necessary step for myosin activation. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
Similar to ML-7, ML-9 is an inhibitor of MLCK. By inhibiting MLCK, the phosphorylation of myosin light chain is reduced, leading to decreased myosin activation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor. ROCK is involved in the regulation of myosin light chain phosphorylation, and its inhibition can decrease myosin activity. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of formins, proteins involved in actin polymerization. Though it primarily affects actin, the result can indirectly influence the actin-myosin interaction. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 is another potent ROCK inhibitor. By inhibiting ROCK, it indirectly impacts the phosphorylation state of myosin light chain and, hence, its activation. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is an inhibitor of protein kinase A (PKA). PKA can phosphorylate and regulate various proteins involved in the myosin activation pathway. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö 6976 is a protein kinase C (PKC) inhibitor. PKC plays a role in myosin light chain phosphorylation, and its inhibition can affect myosin activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U-0126 is an inhibitor of MAPK/ERK kinase. This kinase affects various cellular processes, including those linked to myosin expression and activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP-600125 is a selective JNK inhibitor. The JNK pathway has links to cellular processes related to muscle contraction and myosin activity. | ||||||