MYBPHL Activators
MYBPHL Activators encompass a diverse range of chemical compounds that drive the functional enhancement of the muscle-binding protein MYBPHL through distinct and intricate signaling pathways. For instance, activators like Forskolin and Dibutyryl cAMP work by upregulating intracellular cAMP levels, which leads to the activation of PKA, a kinase that directly phosphorylates MYBPHL, augmenting its role in muscle contraction. Similarly, IBMX maintains elevated cAMP by inhibiting its degradation, thereby indirectly potentiating PKA-mediated phosphorylation of MYBPHL. Epigallocatechin gallate (EGCG) contributes to this regulatory landscape by inhibiting competitive protein kinases, which could lead to a relative increase in MYBPHL phosphorylation by available PKA. In contrast, Anisomycin activates stress-related kinases that could phosphorylate MYBPHL, and PMA activates PKC, another kinase that may target MYBPHL, suggesting a web of regulatory interactions that converge on the enhancement of MYBPHL function.
Beyond cAMP and kinase modulated pathways, additional molecules like Sildenafil and Betaine provide alternative mechanisms for MYBPHL activation. Sildenafil, by augmenting cGMP levels, indirectly enhances cAMP levels, further contributing to the PKA activation cascade that favors MYBPHL phosphorylation. ZnCl2, through its potential action as a signaling modulator, may enhance MYBPHL by directly stabilizing its structure or function. Lithium Chloride's inhibition of GSK-3 could lead to a favorable phosphorylation environment for MYBPHL, providing yet another layer of activation potential. Lastly, AICAR's activation of AMPK suggests a systemic approach to enhancing MYBPHL activity, in line with the energy demands of muscle metabolism, while Curcumin's inhibition of NF-κB signaling may reduce competitive kinase interactions, resulting in enhanced MYBPHL functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate MYBPHL, thereby enhancing its functional activity within muscle cells. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, enzymes responsible for breaking down cAMP. By preventing cAMP degradation, IBMX indirectly increases PKA activity, which can then enhance the function of MYBPHL. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can inhibit various protein kinases, potentially reducing competitive phosphorylation activities. This may lead to a relative increase in the phosphorylation and activation of MYBPHL by kinases such as PKA. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cell-permeable analog of cAMP that activates PKA. Activated PKA can phosphorylate MYBPHL, which would enhance its activity in regulating muscle contraction. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs). Activation of SAPKs can result in the phosphorylation of specific muscle proteins, potentially including MYBPHL, enhancing its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analog that activates protein kinase C (PKC). PKC can phosphorylate target proteins in muscle cells, possibly leading to the activation of MYBPHL. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK can lead to the phosphorylation of various downstream targets, which may include MYBPHL, thereby enhancing its activity in muscle metabolism. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc chloride can act as a signal transduction modulator. Zinc ions might stabilize MYBPHL structure or function by binding to regulatory sites, which could enhance its activity in muscle cells. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium ions inhibit glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 may lead to altered phosphorylation states of various proteins, potentially enhancing the activity of MYBPHL as a result. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine serves as an osmolyte and methyl donor in cells, potentially affecting muscle function. It may indirectly enhance MYBPHL activity by stabilizing the cellular environment and promoting optimal protein function. | ||||||