Mx2 Inhibitors
Common Mx2 Inhibitors include, but are not limited to Cycloheximide CAS 66-81-9, Actinomycin D CAS 50-76-0, Dexamethasone CAS 50-02-2, Pyrrolidinedithiocarbamic acid ammonium salt CAS 5108-96-3 and SP600125 CAS 129-56-6.
Mx2, also known as MX dynamin-like GTPase 2, is a member of the large Mx protein family. These proteins are characterized by their dynamin-like properties and have a crucial role in the cell's defense against various pathogens, especially viruses. Mx2 has been particularly associated with anti-viral defense mechanisms in cells. The protein achieves this by interfering with the life cycle of the virus inside the host cell, blocking its ability to replicate and spread. The action mechanism of Mx2 is complex and involves GTP hydrolysis and interactions with various viral and host proteins. Its role as an intracellular defense molecule makes it an interesting target for studies related to innate immunity and antiviral responses.
Mx2 inhibitors are chemical entities designed to attenuate or completely block the function of Mx2. By inhibiting Mx2 activity, these compounds can modulate the host's innate immune response to viral infections. The design and study of Mx2 inhibitors can provide insights into the protein's detailed mechanism of action and its interactions with other proteins. The action of Mx2 inhibitors might encompass a range of mechanisms, from disrupting the protein's GTPase activity to preventing its interaction with crucial viral or host molecules. Understanding the intricacies of Mx2 inhibition offers a deeper comprehension of the host's primary defense mechanisms against viruses and how these can be modulated. This knowledge can pave the way for more extensive studies into the dynamics of host-pathogen interactions and the molecular basis of innate immunity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide blocks the elongation step in protein synthesis. By inhibiting this step, it might prevent the synthesis of Mx2, leading to reduced levels of the protein in cells. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA, preventing the RNA polymerase from carrying out transcription. This action could inhibit the production of Mx2 mRNA, leading to a subsequent decrease in Mx2 protein levels. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could modulate the immune response by inhibiting interferon production or action. Since Mx2 is an interferon-inducible protein, this glucocorticoid might lead to reduced expression of Mx2. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC can inhibit the NF-κB pathway. Given that NF-κB might regulate interferon responses, PDTC could potentially down-regulate Mx2 expression by inhibiting this transcription factor. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits the JNK signaling pathway. If JNK is involved in the upregulation of Mx2 in response to interferons, its inhibition might lead to reduced Mx2 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 prevents the degradation of proteins by the proteasome. If Mx2 undergoes rapid turnover via proteasomal degradation, MG132 might stabilize other proteins that, in turn, down-regulate Mx2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can modulate various signaling pathways. Depending on the cellular context, quercetin might inhibit pathways or transcription factors responsible for the upregulation of Mx2, leading to its reduced expression. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 inhibits the JAK-STAT signaling pathway. Since interferon responses often involve JAK-STAT signaling, this compound might down-regulate Mx2 by blocking this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits the PI3K-Akt signaling pathway. If Mx2 expression is regulated by PI3K-Akt signaling, its inhibition might lead to reduced Mx2 levels. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits the p38 MAPK pathway. If p38 MAPK signaling plays a role in the upregulation of Mx2, its inhibition might lead to reduced expression of the protein. | ||||||