MTERFD3 Inhibitors
Chemical inhibitors of MTERFD3 employ a variety of mechanisms to modulate the protein's function. Auranofin targets the thioredoxin-thioredoxin reductase system, leading to an accumulation of reactive oxygen species (ROS) that can result in oxidative damage to proteins, including MTERFD3. Similarly, Ebselen acts as a glutathione peroxidase mimic, modulating oxidative stress, and potentially contributing to the oxidative modification and inhibition of MTERFD3. Genistein, as a tyrosine kinase inhibitor, can lead to decreased phosphorylation of proteins in signaling pathways involving MTERFD3, thereby inhibiting its function. PD173074, a selective FGFR inhibitor, can obstruct downstream signaling pathways that involve MTERFD3, leading to its inhibition. Another inhibitor, LY294002, prevents PI3K from activating AKT phosphorylation, which can disrupt cellular processes that involve MTERFD3.
Furthermore, U0126, by inhibiting MEK1/2 and thereby preventing the activation of ERK1/2, can reduce the activity of MTERFD3 if it is a part of the ERK signaling network. Inhibition with SB203580 impedes the p38 MAPK pathway, potentially inhibiting MTERFD3 if it is associated with this pathway. SP600125, which inhibits JNK, can affect MTERFD3's function if MTERFD3 is involved in JNK-related pathways, including apoptosis. Proteasomal inhibitors like Bortezomib and MG132 can lead to the accumulation of misfolded or ubiquitinated MTERFD3, respectively, resulting in its functional inhibition due to improper folding or blocked degradation. Withaferin A can modify the function of MTERFD3 through the covalent modification of its cysteine residues. Lastly, Oligomycin A inhibits ATP synthase, potentially reducing ATP levels necessary for MTERFD3's activity, thereby inhibiting its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin inhibits the thioredoxin-thioredoxin reductase system, which could lead to the accumulation of reactive oxygen species (ROS) that could damage various proteins, including MTERFD3, by oxidative modification. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen acts as a glutathione peroxidase mimic and can modulate oxidative stress within the cell. Elevated oxidative stress could oxidatively modify MTERFD3, leading to its functional inhibition. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor; blocking tyrosine kinases can lead to decreased phosphorylation of proteins involved in the same pathways as MTERFD3, potentially inhibiting its function. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is a selective FGFR inhibitor. By inhibiting FGFR, downstream signaling pathways involving MTERFD3 could be inhibited, leading to the functional inhibition of MTERFD3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can suppress AKT phosphorylation. This inhibition could disrupt cellular processes in which MTERFD3 is involved, thereby inhibiting its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, which prevents the activation of ERK1/2. As ERK is involved in many signaling pathways, its inhibition can lead to a reduction in MTERFD3 activity if MTERFD3 is part of the ERK-related signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, and by disrupting the p38 pathway, it can inhibit processes that are essential for MTERFD3's function, leading to the inhibition of MTERFD3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which can affect apoptosis and other cellular processes. If MTERFD3 is involved in these JNK-related pathways, the inhibition of JNK could result in the functional inhibition of MTERFD3. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, which could result in the accumulation of misfolded or damaged proteins, including potentially MTERFD3, leading to its functional inhibition due to improper folding or degradation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is an inhibitor of the ubiquitin-proteasome pathway. This can lead to the accumulation of polyubiquitinated proteins, possibly including MTERFD3, thus inhibiting its function due to the prevention of its degradation. | ||||||