MS4A7 Inhibitors
MS4A7 Inhibitors focus on the regulation of the immune system, as MS4A7 is an immune-associated protein. Dexamethasone acts through the glucocorticoid receptor to suppress the transcription of pro-inflammatory cytokines, which might influence the activity of MS4A7 due to MS4A7's role in immune responses. Cyclosporin A and rapamycin are other key examples, with the former inhibiting calcineurin to prevent NFAT-mediated transcription of immune response genes, and the latter inhibiting mTOR to curb T-cell activation; both of which are essential for the full functional repertoire of MS4A7. By controlling these transcription factors, these compounds can indirectly cause reduced functional activity of MS4A7.
Inhibitors targeting signaling pathways also play a significant role. U0126, a MEK1/2 inhibitor, and PD98059, another MEK inhibitor, prevent the activation of the ERK pathway, which is essential for cell division, differentiation, and survival. This pathway is particularly important in immune cells, and its inhibition may lead to a reduced immune response, potentially resulting in decreased MS4A7 activity. This is because the ERK pathway is often upstream of transcription factors and other molecules that regulate the expression and function of various immune-associated proteins, including MS4A7.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoid receptor agonist that translocates into the nucleus and acts as a transcription factor for glucocorticoid response elements. This leads to the expression of anti-inflammatory proteins while repressing the transcription of pro-inflammatory cytokines. MS4A7 is associated with immune responses; thus, elevated anti-inflammatory signaling can indirectly lead to the suppression of MS4A7 activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Calcineurin inhibitor that prevents the dephosphorylation and activation of the nuclear factor of activated T-cells (NFAT). NFAT is crucial for the transcription of immune response genes, including those that might regulate MS4A7. Inhibition of NFAT activation can indirectly inhibit MS4A7 functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that blocks the downstream signaling pathways necessary for T-cell proliferation and activation. By inhibiting these pathways, rapamycin indirectly decreases the activation of immune cells, which could lead to a reduction in MS4A7 activity as it is involved in the immune system. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB pathway inhibitor that blocks the phosphorylation of IκBα, preventing NF-κB from translocating to the nucleus and activating immune response genes. Because MS4A7 is part of the immune system, inhibiting NF-κB can decrease the functional activity of MS4A7. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that leads to the suppression of the AKT signaling pathway, which is involved in survival, proliferation, and growth of cells. This inhibition can reduce the functional activity of immune cells, potentially decreasing the activity of MS4A7. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src family kinase inhibitor that interferes with T cell receptor signaling, thereby impacting T cell activation and proliferation. As MS4A7 is related to immune cell activity, PP2 can indirectly reduce MS4A7 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that affects cytokine production and T-cell differentiation. By inhibiting p38 MAPK, SB203580 can indirectly lead to decreased activity of immune cells and consequently MS4A7. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that blocks the activation of the MAPK/ERK pathway, which is involved in cellular proliferation and differentiation. Inhibition of this pathway can lead to reduced immune cell activity, thereby indirectly inhibiting MS4A7. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that blocks the AKT signaling pathway, leading to reduced cell growth and survival. This can indirectly lead to the inhibition of MS4A7 by impairing immune cell function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A natural compound that can inhibit the activation of NF-κB. By preventing NF-κB from entering the nucleus and activating immune response genes, curcumin can indirectly suppress the activity of MS4A7. | ||||||