MS4A18 Inhibitors
MS4A18 inhibitors encompass a broad spectrum of chemical compounds that indirectly influence the functional activity of MS4A18 by targeting various signaling pathways and cellular processes with which MS4A18 may be associated. For example, compounds like Wortmannin and LY294002 directly inhibit PI3K, leading to the suppression of the AKT signaling pathway, a crucial mediator of cellular survival and proliferation signals. If MS4A18 is part of the PI3K/AKT pathway, then inhibitors such as Wortmannin and LY294002 could potentially decrease the activity of MS4A18 by disrupting this signaling cascade. This could lead to downstream effects on cell survival, proliferation, and other cellular functions that are regulated by the PI3K/AKT pathway and potentially involve MS4A18.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphatidylinositol 3-kinase (PI3K). By inhibiting PI3K, it reduces AKT phosphorylation, which is critical for survival signaling. If MS4A18 is involved in a cell survival pathway regulated by PI3K/AKT, wortmannin would lead to the inhibition of MS4A18's function by impeding the pathway's activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that prevents the phosphorylation of AKT. Inhibition of PI3K by LY294002 could lead to reduced MS4A18 activity if MS4A18 is part of signaling cascades downstream of PI3K/AKT, as this would disrupt the signal transduction necessary for MS4A18's functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a kinase involved in cell growth and protein synthesis. If MS4A18 function is linked to these processes, rapamycin would decrease MS4A18 activity by reducing the protein synthesis and cell growth signaling that may involve MS4A18. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. If MS4A18's function is regulated by phosphorylation through various kinases, staurosporine would inhibit these kinases, leading to reduced phosphorylation and thus decreased MS4A18 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a specific inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. If MS4A18 is regulated by the MAPK pathway, U0126 would inhibit MS4A18 activity by preventing its phosphorylation through the ERK signaling cascade. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). If MS4A18 is modulated by stress response signals through the JNK pathway, SP600125 would inhibit these signals, thus reducing MS4A18 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAPK. If MS4A18 is implicated in inflammatory responses or stress signaling mediated by p38 MAPK, inhibition by SB203580 would lead to decreased MS4A18 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which acts upstream of ERK. By inhibiting MEK and thus blocking ERK activation, PD98059 would decrease MS4A18 activity if MS4A18 is regulated by the ERK signaling pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src-family tyrosine kinase inhibitor. If MS4A18 is activated or regulated by Src-family kinases, PP2 would lead to decreased MS4A18 activity by preventing its activation through these tyrosine kinases. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits protein transport by interfering with the ADP-ribosylation factor. If MS4A18 requires proper membrane localization for its activity, brefeldin A would inhibit MS4A18 function by blocking its transport to the cell membrane. | ||||||