MRP2 Substrates

Santa Cruz Biotechnology now offers a broad range of MRP2 Substrates for use in various applications. Multidrug resistance-associated protein 2 (MRP2), also known as ABCC2, is a critical member of the ATP-binding cassette (ABC) transporter family, which is involved in the efflux of a wide variety of organic anions, including drugs, toxins, and endogenous compounds such as bilirubin conjugates and glutathione conjugates. MRP2 is primarily expressed in the liver, kidney, and intestine, where it plays a vital role in the excretion of these substances into bile and urine, thus contributing to the body's detoxification processes. MRP2 Substrates are indispensable tools in scientific research, enabling researchers to study the transport activity of MRP2 and its role in the pharmacokinetics of drugs, particularly in the context of drug disposition and resistance. By using these substrates, scientists can investigate how MRP2 mediates the cellular export of various compounds, which is crucial for understanding its function in drug metabolism and its impact on the effectiveness and safety of agents. These substrates are widely employed in studies aimed at explaining the mechanisms of drug resistance, particularly in cancer and liver diseases, where altered MRP2 activity can significantly affect treatment outcomes. Furthermore, MRP2 Substrates are valuable for screening potential drug interactions and developing inhibitors that can modulate MRP2 activity to improve drug efficacy. The availability of these substrates has greatly advanced research in toxicology and molecular biology, providing essential insights into the complex dynamics of transporter-mediated drug transport and resistance. View detailed information on our available MRP2 Substrates by clicking on the product name.