MRP-L10 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a mTOR inhibitor which can halt ribosomal biogenesis by blocking the function of MRP-L10, a part of the large ribosomal subunit. This, in turn, causes a decrease in protein synthesis, indirectly inhibiting the functional activity of MRP-L10. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which can interrupt the PI3K/AKT/mTOR pathway. By inhibiting this pathway, the activity of MRP-L10 can be reduced as the ribosomal biogenesis that MRP-L10 is involved in is downregulated. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that can halt the PI3K/AKT/mTOR pathway. The reduced activity in this pathway can lead to decreased ribosomal biogenesis, thereby indirectly inhibiting the function of MRP-L10. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glucose analogue that inhibits glycolysis. Since ribosomal biogenesis is an energy-intensive process, reduced energy availability can indirectly inhibit the functional activity of MRP-L10. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits PI3K, leading to a reduction in the PI3K/AKT/mTOR pathway activity. This leads to decreased ribosomal biogenesis, indirectly inhibiting the function of MRP-L10. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib is a Raf kinase inhibitor, which can interrupt the Raf/MEK/ERK pathway. This can indirectly inhibit the function of MRP-L10 as the pathway is linked to mTOR, which controls ribosomal biogenesis. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide is an mTORC1 inhibitor which can decrease ribosomal biogenesis, indirectly inhibiting the functional activity of MRP-L10. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is a mTOR inhibitor that can halt the mTOR pathway, leading to a decrease in ribosomal biogenesis. This can indirectly inhibit the functional activity of MRP-L10. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
NVP-BEZ235 is a dual PI3K/mTOR inhibitor. By inhibiting both PI3K and mTOR, it can decrease ribosomal biogenesis, indirectly inhibiting the functional activity of MRP-L10. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
Selumetinib is a MEK inhibitor which can interrupt the Raf/MEK/ERK pathway. This can indirectly inhibit the function of MRP-L10 as the pathway is linked to mTOR, which controls ribosomal biogenesis. | ||||||