MOB2 Activators
MOB2 activators consist of chemicals that indirectly modulate various cellular pathways that can lead to the activation of MOB2. These compounds exert their influence through the modification of signaling cascades, often affecting the phosphorylation states of multiple proteins within the cell, altering interactions and functions related to MOB2. For instance, molecules like Forskolin and IBMX elevate intracellular cAMP levels, which activates PKA, a kinase that can phosphorylate several proteins, including those associated with MOB2, leading to its activation. Similarly, agents such as PMA and Roscovitine can alter the activity of key enzymes like PKC and CDKs, respectively, resulting in cellular changes that could influence the regulation and activation of MOB2.
Additionally, chemicals such as Lithium Chloride, LY294002, and Rapamycin interfere with specific signaling pathways like GSK-3beta, PI3K/AKT, and mTOR, respectively. These inhibitors cause a shift in cellular equilibrium, prompting feedback mechanisms that may engage compensatory pathways impacting MOB2 function. The use of pathway inhibitors such as U0126, SB203580, PD98059, and SP600125 can result in the activation of alternative signaling routes or stress responses that affect MOB2 indirectly. This indicates the intricate web of cellular signaling networks where the inhibition of one pathway can result in the upregulation or activation of another, which in turn, could modulate proteins such as MOB2. Lastly, compounds like 2-Deoxy-D-glucose put the cell under metabolic stress, activating AMPK and influencing pathways wherein MOB2 might be involved.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase which increases cAMP levels in cells, leading to the activation of PKA. PKA can phosphorylate a multitude of proteins and may promote the phosphorylation of factors that can interact with or modify MOB2, leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which increases cAMP and cGMP levels in cells. Elevated cAMP/cGMP may activate PKA and PKG, respectively, which could then phosphorylate and modulate the function of proteins that interact with MOB2, indirectly contributing to its activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
An inhibitor of GSK-3beta, leading to activation of the Wnt signaling pathway. While direct interaction with MOB2 is not established, GSK-3beta inhibition can result in altered cellular dynamics that might indirectly affect MOB2 activity, since MOB2 is implicated in cell cycle regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
An activator of Protein Kinase C (PKC) which influences many cellular processes. PKC activation can lead to changes in the phosphorylation state of many proteins within the cell, potentially including those that associate with MOB2, resulting in its functional modulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor which can modulate the AKT signaling pathway. Inhibition of this pathway often results in feedback loops that alter other signaling cascades, which could intersect with those regulating MOB2 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor which can lead to a complex response, often involving the upregulation of AKT signaling as a feedback mechanism. Through these regulatory networks, the activity of proteins associated with MOB2 could be affected. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor which may activate compensatory pathways within the cell that affect MOB2. By modulating cellular stress response pathways, SB203580 could influence the phosphorylation state and activation of MOB2 indirectly. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An ERK pathway inhibitor, which could alter cellular signaling networks and potentially impact the regulation of MOB2 through compensatory mechanisms within the cell. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which could result in the activation of alternative signaling pathways or stress responses that indirectly modulate MOB2 activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A selective inhibitor of cyclin-dependent kinases (CDKs), which may lead to alterations in cell cycle regulation and could have downstream effects on MOB2 activity. | ||||||