Date published: 2026-5-16

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mGluR-7 Activators

mGluR-7 Activators are a class of chemical compounds that selectively enhance the activity of the metabotropic glutamate receptor 7 (mGluR-7), a G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system. mGluR-7 is part of the group III mGluRs, which play a crucial role in modulating neurotransmission and synaptic plasticity by responding to the neurotransmitter glutamate. Unlike ionotropic glutamate receptors, mGluR-7 does not directly mediate fast synaptic transmission but instead modulates it through second messenger systems, influencing neuronal excitability and synaptic strength. mGluR-7 activators bind to the receptor and enhance its response to glutamate, potentially by stabilizing the receptor in an active conformation or by facilitating the receptor's interaction with its G proteins, thereby modulating downstream signaling pathways. The study and characterization of mGluR-7 activators involve detailed analyses of their binding properties, efficacy, and specificity. These compounds are often evaluated through a combination of in vitro assays and structural biology techniques to understand their interaction with mGluR-7 at a molecular level. By activating mGluR-7, researchers can investigate its role in various physiological processes, such as synaptic transmission, plasticity, and the regulation of neurotransmitter release. mGluR-7 is particularly interesting because it is primarily located at presynaptic sites, where it acts as a modulator of neurotransmitter release, typically exerting an inhibitory effect. Activators of mGluR-7 are therefore valuable tools for studying the receptor's involvement in synaptic function, including its influence on the balance of excitatory and inhibitory signals in the brain. Through these studies, scientists can gain insights into the complex regulatory mechanisms of neurotransmission and the broader implications of mGluR-7 activity in neuronal networks.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

AMN082 dihydrochloride

83027-13-8sc-200483
sc-200483A
10 mg
50 mg
$125.00
$510.00
(0)

AMN082 dihydrochloride is a potent allosteric modulator of the mGluR-7 receptor, characterized by its ability to stabilize specific receptor conformations. This compound engages in unique molecular interactions that fine-tune receptor signaling pathways, leading to altered intracellular calcium dynamics. Its distinct kinetic properties enable precise modulation of receptor activation, influencing synaptic transmission and neuronal excitability through selective engagement with downstream effectors.

O-Phospho-L-serine

407-41-0sc-202257
1 g
$37.00
(1)

O-Phospho-L-serine serves as a selective activator of the mGluR-7 receptor, exhibiting unique binding affinities that enhance receptor functionality. Its structural features facilitate specific interactions with the receptor's allosteric sites, promoting conformational changes that modulate downstream signaling cascades. This compound influences synaptic plasticity by altering neurotransmitter release dynamics, showcasing distinct reaction kinetics that optimize receptor responsiveness in neural pathways.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

May increase mGluR-7 expression by activating adenylate cyclase, leading to increased cAMP and subsequent activation of PKA, potentially enhancing transcription of certain genes.

(RS)-PPG

120667-15-4sc-202797
5 mg
$71.00
(0)

(RS)-PPG acts as a potent mGluR-7 activator, characterized by its ability to engage with the receptor's unique binding domains. This compound induces specific conformational shifts that enhance receptor activation, influencing intracellular signaling pathways. Its molecular structure allows for selective interactions that fine-tune synaptic transmission, impacting neuronal excitability and plasticity. The kinetics of its binding and activation reveal a nuanced modulation of receptor behavior, contributing to its role in neural communication.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

As an HDAC inhibitor, valproic acid could upregulate mGluR-7 expression by increasing histone acetylation and gene transcription.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

Might demethylate DNA at the mGluR-7 gene promoter, potentially leading to increased expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Could induce mGluR-7 expression by modulating transcription factors and signaling pathways associated with neuronal health.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Might upregulate mGluR-7 indirectly through its influence on various signaling pathways affecting neuronal gene expression.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Might influence mGluR-7 gene expression due to its role in regulating neuronal differentiation and gene expression.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$33.00
$67.00
$97.00
$192.00
$775.00
13
(1)

As a phosphodiesterase inhibitor, could potentially upregulate mGluR-7 by increasing cAMP levels.