MFF Inhibitors

MFF inhibitors encompass a variety of chemicals that indirectly influence the activity of the Mitochondrial fission factor (MFF). These inhibitors do not target MFF directly; instead, they modulate various aspects of mitochondrial dynamics, energy metabolism, and cellular signaling pathways, which in turn can impact the function of MFF. MFF plays a vital role in the process of mitochondrial fission, a key event in mitochondrial and cellular health, and its modulation has implications for the regulation of mitochondrial morphology and function.

Compounds such as Mdivi-1 and Dynasore, known for their roles in inhibiting mitochondrial division and dynamin-related proteins respectively, can indirectly affect the mitochondrial fission process in which MFF is a critical component. Similarly, drugs like Metformin and Resveratrol, which are known for their effects on mitochondrial function, could potentially influence the activity of MFF. NMN, influencing mitochondrial biogenesis, and Cyclosporine A, affecting mitochondrial permeability, also fall under this category, as changes in mitochondrial dynamics can indirectly modulate MFF's role. Further, compounds like Rapamycin, an mTOR inhibitor, and Oligomycin A, which inhibits mitochondrial ATP synthase, impact broader cellular and mitochondrial processes that can, in turn, influence MFF activity. FCCP, a mitochondrial uncoupler, and 2-Deoxy-D-glucose, a glycolysis inhibitor, also play roles in energy metabolism that could potentially affect MFF-mediated mitochondrial fission. Bongkrekic Acid and Rotenone, affecting mitochondrial adenine nucleotide translocator and complex I respectively, demonstrate how alterations in mitochondrial respiratory functions can indirectly impact MFF.