METTL1 Activators

The chemicals categorized as METTL1 Activators primarily operate within the framework of methylation reactions and the cellular environment, exerting their influence indirectly on METTL1's activity. Central to this list is SAM, a universal methyl donor that stands fundamental for the operation of methyltransferases like METTL1. Its availability and cellular levels are vital for ensuring METTL1's function, with related molecules like Vitamin B12 and Folic Acid supporting the methyl cycle and facilitating SAM production, subsequently backing METTL1's activity.

Furthermore, the list encompasses chemicals that recalibrate the broader cellular methylation panorama. Agents like Zebularine and 5-Aza-2'-deoxycytidine, known as DNA methyltransferase inhibitors, alter the methylation state of the genome and can, in turn, influence METTL1's activity in that changed context. Likewise, natural compounds such as EGCG, Genistein, Quercetin, Curcumin, and Resveratrol are recognized for their ability to modulate methylation processes in cells. Their presence can shape the methylation dynamics, offering indirect modulation to enzymes like METTL1.