Med8 Activators
Med8 is a subunit of the mediator complex, a critical multiprotein assembly that acts as a transcriptional coactivator in eukaryotic cells. It functions by conveying regulatory signals from transcription factors to the RNA polymerase II (Pol II) enzyme, which is responsible for synthesizing messenger RNA (mRNA) from DNA templates. The mediator complex, including Med8, is thereby integral to the regulation of gene expression.
The function of Med8 within the mediator complex is to participate in the transduction of signals from specific gene regulatory elements to the general transcription machinery. It is involved in the critical processes of transcription initiation and elongation. By examining the effects of Med8 activators, researchers could gain valuable insights into the regulation of transcription and the role of the mediator complex in various cellular processes, such as development, cell differentiation, and response to environmental cues. Understanding the mechanism of action of Med8 activators would be instrumental in dissecting the complex pathways of gene regulation and could illuminate new aspects of chromatin organization and the dynamics of the transcription machinery.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Galactose | 59-23-4 | sc-202564 | 100 g | $288.00 | 4 | |
Galactose is a monosaccharide that can activate Med8 indirectly through its influence on the galactose utilization pathway. Med8, as a component of the Mediator complex, plays a role in transcription regulation where galactose-responsive genes are involved. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. Upon activation by dexamethasone, the glucocorticoid receptor can induce transcription of genes where Med8 is involved in the regulation process, thus indirectly activating Med8. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, elevating intracellular cAMP levels. This can activate protein kinase A (PKA), which can phosphorylate various transcription factors. Med8, being part of the Mediator complex involved in transcription, can be indirectly activated as a result. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is an active metabolite of Vitamin A that binds to the retinoic acid receptor (RAR). This binding event can induce the transcription of genes where Med8, as part of the Mediator complex, plays a role in the transcription regulation, thus indirectly activating Med8. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol is an estrogen receptor agonist. Upon activation by estradiol, the estrogen receptor can induce transcription of genes where Med8 is involved in the regulation process, thus indirectly activating Med8. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to a more relaxed chromatin structure. This promotes transcription where Med8, as a component of the Mediator complex, can be indirectly activated. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases cellular levels of cAMP, activating PKA. This can lead to phosphorylation of various transcription factors, indirectly activating Med8 through its role in the Mediator complex. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation. This leads to altered expression of numerous genes and, as part of the Mediator complex, Med8 can be indirectly activated. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that leads to a more open chromatin structure. This promotes transcription where Med8, as a component of the Mediator complex, can be indirectly activated. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which leads to an increase in cAMP levels in cells. This can activate PKA which phosphorylates several transcription factors, indirectly activating Med8 through its role in the Mediator complex. | ||||||