MDM2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RG-7112 | 939981-39-2 | sc-507292 | 10 mg | $520.00 | ||
RG7112 is an active MDM2 inhibitor that disrupts the MDM2-p53 interaction, resulting in p53 activation. It has shown promising results in early research studies against various cancers. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 is a selective inhibitor of the MDM2 protein, known for its ability to disrupt the MDM2-p53 interaction. This compound stabilizes p53 by preventing MDM2-mediated ubiquitination, leading to enhanced p53 activity. Nutlin-3 exhibits unique binding affinity through a series of π-π stacking and hydrophobic interactions, which fine-tune its specificity. Its structural conformation allows for effective modulation of cellular stress responses, influencing apoptotic pathways. | ||||||
HLI 373 | 502137-98-6 | sc-358833 sc-358833A | 10 mg 50 mg | $173.00 $712.00 | 1 | |
HLI 373 is a potent antagonist of the MDM2 protein, characterized by its ability to selectively disrupt the MDM2-p53 complex. This compound engages in specific hydrogen bonding and hydrophobic interactions, enhancing its binding affinity. HLI 373's unique structural features facilitate the stabilization of p53, promoting its transcriptional activity. The compound's kinetic profile suggests rapid engagement with MDM2, influencing cellular regulatory mechanisms and apoptosis. | ||||||
JNJ 26854165 | 881202-45-5 | sc-364514 sc-364514A | 5 mg 25 mg | $168.00 $566.00 | ||
JNJ 26854165 is a selective inhibitor of the MDM2 protein, distinguished by its unique binding dynamics that involve intricate π-π stacking and van der Waals interactions. This compound exhibits a remarkable ability to alter the conformational landscape of MDM2, leading to a significant disruption of its interaction with p53. The kinetic behavior of JNJ 26854165 indicates a fast on-rate, allowing for efficient modulation of cellular pathways related to tumor suppression and cell cycle regulation. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $120.00 $215.00 | 2 | |
(–)-Nutlin-3 is a potent antagonist of the MDM2 protein, characterized by its specific binding affinity that stabilizes the p53-MDM2 complex. This compound engages in hydrogen bonding and hydrophobic interactions, effectively preventing MDM2 from ubiquitinating p53. Its unique structural conformation enhances selectivity, promoting a favorable kinetic profile that facilitates rapid engagement with target sites, thereby influencing cellular stress response mechanisms. | ||||||
MDM2 Inhibitor Inhibitor | 562823-84-1 | sc-204072 | 10 mg | $172.00 | ||
MDM2 Inhibitor is a selective modulator of the MDM2 protein, exhibiting a unique ability to disrupt the MDM2-p53 interaction. This compound features a distinct molecular architecture that allows for precise steric hindrance, effectively blocking MDM2's E3 ligase activity. Its interactions are characterized by a combination of van der Waals forces and electrostatic interactions, which contribute to its stability and efficacy in altering protein dynamics within cellular pathways. | ||||||
NSC 66811 | 6964-62-1 | sc-311507 sc-311507A | 10 mg 50 mg | $159.00 $670.00 | ||
NSC 66811 is a potent MDM2 antagonist that showcases a unique binding affinity for the MDM2 protein, effectively altering its conformation. This compound engages in specific hydrogen bonding and hydrophobic interactions, enhancing its selectivity. Its kinetic profile reveals a rapid association and slower dissociation, indicating a strong and sustained interaction with MDM2. This behavior influences downstream signaling pathways, ultimately impacting cellular responses to stress. | ||||||
Caylin-1 | sc-223878 sc-223878A | 1 mg 5 mg | $101.00 $338.00 | |||
Caylin-1 acts as a selective MDM2 inhibitor, characterized by its ability to disrupt the MDM2-p53 interaction. This compound exhibits unique electrostatic interactions and a distinct hydrophobic pocket engagement, which stabilizes its binding. The reaction kinetics of Caylin-1 demonstrate a notable affinity, with a fast on-rate and a prolonged off-rate, leading to effective modulation of cellular pathways. Its structural properties facilitate specific conformational changes in MDM2, influencing protein stability and function. | ||||||
Caylin-2 | sc-223879 sc-223879A | 1 mg 5 mg | $100.00 $338.00 | |||
Caylin-2 functions as a potent MDM2 antagonist, distinguished by its unique binding dynamics that alter the conformational landscape of the MDM2 protein. It engages in specific hydrogen bonding and hydrophobic interactions, enhancing its affinity for the target. The compound exhibits a rapid association rate, coupled with a slow dissociation, which prolongs its inhibitory effect. Additionally, Caylin-2's structural features promote allosteric modulation, impacting downstream signaling pathways. | ||||||
R5C3 | 753504-14-2 | sc-215783 | 5 mg | $91.00 | ||
R5C3 acts as a selective MDM2 inhibitor, characterized by its ability to form stable complexes through intricate π-π stacking and electrostatic interactions with the MDM2 binding site. This compound demonstrates a unique kinetic profile, exhibiting a fast on-rate and a prolonged off-rate, which enhances its effectiveness in disrupting MDM2's regulatory functions. Furthermore, R5C3's structural rigidity contributes to its specificity, minimizing off-target effects and optimizing its interaction dynamics. | ||||||