MDH2 Inhibitors

Regarding the chemical class MDH2 Inhibitors, these compounds represent a diverse group that can interact with the MDH2 enzyme and potentially inhibit its activity. Their mechanisms of action include competitive inhibition by mimicking substrates or products of the Krebs cycle, interfering with cofactor binding, and structural mimicry of intermediates in the citric acid cycle. These inhibitors range from simple organic acids like malonate to more complex compounds like atovaquone. Their action is centered around modulating the enzymatic activity of MDH2, a crucial component in cellular metabolism. By targeting this enzyme, these inhibitors aim to influence the metabolic processes in which MDH2 is involved, particularly the conversion of malate to oxaloacetate in the citric acid cycle.