MBD3L2 Inhibitors
MBD3L2 Inhibitors are a collection of chemical compounds that influence the methylation state of DNA, which is a critical determinant of MBD3L2 function. MBD3L2 is known to bind methylated DNA, and the presence of methyl groups on DNA is essential for its activity. Chemicals such as 5-Azacytidine and Decitabine act as nucleoside analogs, which get incorporated into DNA during replication and inhibit DNA methyltransferases (DNMTs). This results in a global decrease in DNA methylation levels, reducing the methylation marks that MBD3L2 requires for binding. Consequently, the functional activity of MBD3L2 is inhibited as it cannot effectively recognize and bind its normal methylated DNA targets.
Other compounds like RG108 and SGI-1027 are non-nucleoside inhibitors that directly target DNMTs, preventing them from adding methyl groups to DNA without being incorporated into the DNA strand. By blocking the action of DNMTs, these compounds ensure that the DNA remains unmethylated, which impairs the ability of MBD3L2 to bind to DNA. Similarly, natural compounds such as Epigallocatechin gallate, Quercetin,Oleuropein, and Curcumin also contribute to the inhibition of DNA methylation through various mechanisms like trapping DNMTs, inhibiting enzyme activity, or altering DNMT expression. These actions result in a hypomethylated state of DNA, which in turn inhibits the interaction of MBD3L2 with its typical methylated DNA substrates. The inability of MBD3L2 to engage with methylated DNA results in a functional inhibition of its activity, as its normal biological role is contingent upon this interaction. These compounds, through their varied mechanisms of action, ensure that the methylation-dependent binding of MBD3L2 to DNA is reduced, leading to an inhibition of the functional role of MBD3L2 in cellular contexts where it is normally active.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that reduces DNA methylation levels. MBD3L2 binds to methylated DNA; therefore, by decreasing methylation, 5-Azacytidine can reduce the available binding sites for MBD3L2, leading to its functional inhibition. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that prevents DNA methylation. By impeding the addition of methyl groups to DNA, RG108 limits MBD3L2's ability to interact with methylated DNA, thus inhibiting its functional role. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A hypomethylating agent that incorporates into DNA and inhibits DNA methyltransferase. This action results in a decreased DNA methylation state, leading to a reduction in MBD3L2 binding to DNA and inhibiting its activity. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine analog that traps DNA methyltransferases. Zebularine reduces the methylation of DNA, which in turn can decrease the binding of MBD3L2 to methylated DNA, effectively inhibiting its function. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
A DNA demethylating agent that nonspecifically inhibits DNA methyltransferases. Procaine's inhibition of methylation can reduce the ability of MBD3L2 to bind methylated DNA, thus indirectly decreasing its activity. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
An antihypertensive agent that also acts as a DNA demethylating agent. By inhibiting DNA methylation, hydralazine can lead to reduced MBD3L2 binding to DNA due to the lack of methylated cytosines, inhibiting its function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea with DNA demethylating activity. It can decrease DNA methylation, which would inhibit MBD3L2's ability to bind to methylated DNA sites, thus inhibiting its functional activity. | ||||||
SGI-1027 | 1020149-73-8 | sc-473875 | 10 mg | $213.00 | ||
A small molecule inhibitor of DNA methyltransferases. By decreasing DNA methylation, SGI-1027 reduces the binding affinity of MBD3L2 for methylated DNA, thereby inhibiting its activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An aldehyde dehydrogenase inhibitor that has been shown to have DNA demethylating properties. Disulfiram can lead to decreased methylation levels of DNA, thereby reducing MBD3L2's ability to bind to its methylated DNA substrates. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid with DNA demethylating activity. Quercetin inhibits DNA methyltransferases, leading to reduced DNA methylation and consequently inhibiting MBD3L2's binding to methylated DNA. | ||||||