Matriptase-2 Activators
Matriptase-2 Activators are compounds that indirectly enhance the activity of Matriptase-2 (TMPRSS6) primarily through the modulation of iron homeostasis and related signaling pathways. Sodium orthovanadate, as a phosphatase inhibitor, ensures the phosphorylation state necessary for Matriptase-2's proteolytic activity. Hepcidin, a central regulator of iron homeostasis, influences Matriptase-2 indirectly; by reducing iron levels, it increases TMPRSS6 expression and activity. Similarly, BMP6, by regulating hepcidin expression, impacts Matriptase-2 activity. Compounds like Cobalt(II) chloride and HIF-1α stabilizers (e.g., Roxadustat) mimic hypoxic conditions, leading to a decrease in hepcidin levels, which is inversely related to Matriptase-2 activity. Deferasirox, an iron chelator, and dietary compounds such as EGCG, Ascorbic Acid, Curcumin, and Quercetin, all influence iron metabolism and hepcidin levels, thereby indirectly modulating Matriptase-2 activity.
The relationship between Matriptase-2 and iron regulatory pathways is further highlighted by the effects of IL-6 inhibitors like Tocilizumab, which reduce hepcidin levels, thus indirectly enhancing Matriptase-2 activity. Lactoferrin, with its role in iron binding and modulation, also impacts Matriptase-2 activity through iron homeostasis pathways. Collectively, these Matriptase-2 Activators demonstrate the protein's critical involvement in iron regulation, with various compounds influencing its activity through direct biochemical interactions or by modulating the expression and action of hepcidin.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate acts as a phosphatase inhibitor. By inhibiting phosphatases that can dephosphorylate Matriptase-2, it can lead to enhanced activation of Matriptase-2, ensuring its proteolytic activity remains unimpeded. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt(II) chloride can mimic hypoxic conditions, leading to decreased hepcidin expression. This reduction in hepcidin can subsequently enhance Matriptase-2 activity, as Matriptase-2 is negatively regulated by hepcidin. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $180.00 | 9 | |
Deferasirox is an iron chelator. By reducing cellular iron levels, it can lead to decreased hepcidin levels and thereby enhance Matriptase-2 activity, as Matriptase-2 is involved in the negative regulation of hepcidin. | ||||||
N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine-d3 | 808118-40-3 unlabeled | sc-488006 | 10 mg | $12000.00 | ||
HIF-1α stabilizers like Roxadustat mimic hypoxia, leading to decreased hepcidin production. This reduction in hepcidin can result in increased Matriptase-2 activity due to the inverse relationship between hepcidin and TMPRSS6 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, has been shown to influence iron metabolism. By potentially reducing hepcidin levels, EGCG can indirectly enhance Matriptase-2 activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic Acid (Vitamin C) enhances iron absorption and utilization, potentially decreasing hepcidin levels and thereby indirectly enhancing Matriptase-2 activity through iron regulatory pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, known for its anti-inflammatory properties, may influence iron metabolism and hepcidin levels. This can indirectly lead to enhanced Matriptase-2 activity due to the protein's role in hepcidin regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has been reported to influence iron homeostasis. By potentially modulating hepcidin levels, it can indirectly enhance Matriptase-2 activity. | ||||||
Lactoferrin | 146897-68-9 | sc-394420 sc-394420A sc-394420B sc-394420C | 10 mg 50 mg 100 mg 1 g | $122.00 $408.00 $580.00 $1494.00 | ||
Lactoferrin, involved in iron binding and modulation, can influence hepcidin levels. This modulation of iron homeostasis can indirectly lead to enhanced activity of Matriptase-2. | ||||||