MAS1L Activators
Chemical activators of the MAS1L protein include a variety of compounds that engage different signaling pathways, leading to the functional activation of this G-protein-coupled receptor (GPCR). Angiotensin II, a potent vasoconstrictor peptide hormone, can activate MAS1L by binding to its receptors, which triggers the intracellular IP3/DAG pathway that culminates in the release of calcium from intracellular stores. Similarly, lysophosphatidic acid and endothelin-1 also operate through GPCR-mediated activation of phospholipase C, resulting in the production of IP3 and the subsequent increase of intracellular calcium levels, which can activate MAS1L. Sphingosine-1-phosphate, another lipid mediator, engages GPCRs that can activate the Rho/Rac pathway, which may lead to MAS1L activation through alterations in cytoskeletal dynamics.
Furthermore, thrombin, a serine protease, activates protease-activated receptors (PARs) that can lead to MAS1L activation through G-protein signaling pathways that involve the mobilization of calcium. Bradykinin, acting through its B2 receptors, and norepinephrine, through alpha-adrenergic receptors, both result in elevated intracellular calcium, which can activate MAS1L. Chemicals like aluminium fluoride stabilize G-proteins in their active form, potentially leading to MAS1L activation via changes in intracellular cAMP or calcium levels. The calcium ionophore A23187 directly increases intracellular calcium concentration, activating MAS1L. The peptide melittin stimulates phospholipase A2, leading to eicosanoid production, which can activate GPCRs and in turn MAS1L. U46619, a synthetic analog of thromboxane A2, activates thromboxane receptors and engages G-protein signaling pathways. Lastly, arginine vasopressin, by binding to vasopressin receptors, also causes an increase in intracellular calcium levels, which can lead to the activation of MAS1L.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
This peptide hormone can activate MAS1L by binding to its associated G-protein-coupled receptors, leading to activation of intracellular signaling pathways such as IP3/DAG pathway which results in the release of calcium from intracellular stores. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Acts through G-protein-coupled receptors, leading to activation of phospholipase C and subsequent IP3/DAG signaling pathway, which can activate MAS1L by increasing intracellular calcium levels. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Binds to its G-protein-coupled receptors, which may induce activation of the Rho/Rac pathway and potentially lead to the functional activation of MAS1L through changes in cytoskeletal dynamics. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
A serine protease that can activate protease-activated receptors (PARs) which are G-protein-coupled receptors that could lead to the activation of MAS1L through G-protein signaling pathways, particularly those involving Gq proteins and downstream calcium mobilization. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
This peptide activates B2 receptors which are G-protein-coupled and can lead to increased intracellular calcium, thus potentially functionally activating MAS1L through calcium signaling pathways. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
Acts as a G-protein activator by stabilizing the G-protein in an active form, which could then functionally activate MAS1L via downstream signaling pathways that involve changes in intracellular cAMP or calcium levels. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that can increase intracellular calcium concentration and thereby activate MAS1L through calcium-dependent signaling pathways. | ||||||
Melittin | 37231-28-0 | sc-200868 sc-200868A sc-200868B | 500 µg 1 mg 10 mg | $196.00 $339.00 $787.00 | 2 | |
This peptide from bee venom can activate phospholipase A2, leading to the release of arachidonic acid and subsequent production of eicosanoids, which can activate G-protein-coupled receptors and potentially lead to the activation of MAS1L. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $245.00 $1301.00 | 40 | |
A thromboxane A2 analog that activates thromboxane receptors, leading to activation of G-protein signaling pathways and potential functional activation of MAS1L. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Can activate alpha-adrenergic receptors, which are G-protein-coupled and can lead to the activation of phospholipase C, IP3 production, and subsequent calcium release from endoplasmic reticulum, potentially leading to MAS1L activation. | ||||||