Date published: 2025-10-23

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Makorin-1 Inhibitors

Makorin-1 inhibitors are a class of chemical compounds designed to target and inhibit the activity of the Makorin-1 (MKRN1) protein. Makorin-1 is an E3 ubiquitin ligase, meaning it is involved in the process of tagging proteins for degradation via the ubiquitin-proteasome pathway. This protein has several zinc finger domains, which allow it to bind to specific target proteins and regulate their stability by marking them with ubiquitin molecules. Through this mechanism, Makorin-1 plays a critical role in controlling protein turnover and regulating various cellular functions, including transcriptional regulation, RNA processing, and cell cycle control. Inhibitors of Makorin-1 interfere with its ability to ubiquitinate target proteins, thereby affecting the degradation and stability of these proteins within the cell.

The inhibition of Makorin-1 offers valuable insights into the complex regulatory networks involved in maintaining protein homeostasis. By selectively blocking the activity of this E3 ligase, researchers can study the specific roles of proteins that would normally be targeted for degradation, and how their accumulation or altered stability impacts cellular processes. Furthermore, Makorin-1 inhibitors provide a useful tool for understanding the fine-tuned balance between protein synthesis and degradation, especially in pathways that rely on the regulated removal of key proteins. Investigating how cells respond to Makorin-1 inhibition can reveal new details about ubiquitin-mediated regulation and its importance in cellular function, particularly in processes like signal transduction, stress response, and developmental regulation. The use of Makorin-1 inhibitors thus opens up opportunities to explore how disruption of protein turnover influences various biological systems.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A could inhibit histone deacetylase activity, leading to hyperacetylation of histones, which may downregulate MKRN1 transcription by altering chromatin accessibility at its gene locus.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine may decrease methylation of the MKRN1 gene promoter, potentially reducing its transcription by disrupting binding sites for methylation-sensitive transcriptional repressors.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin could inhibit the mTOR pathway, which in turn may decrease the initiation of cap-dependent translation, leading to a reduction in Makorin-1 synthesis.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin may downregulate MKRN1 expression by inhibiting specific kinases involved in the activation of transcription factors that are necessary for MKRN1 gene transcription.

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$68.00
$261.00
8
(1)

By inhibiting inosine monophosphate dehydrogenase, mycophenolic acid could lead to a depletion of guanine nucleotides, which may result in the reduced transcription of the MKRN1 gene.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine may disrupt endosomal acidification, which could lead to altered intracellular trafficking and lysosomal degradation of MKRN1 mRNA, resulting in decreased levels of Makorin-1.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid could bind retinoic acid receptors, which may act as transcriptional repressors for the MKRN1 gene, thereby decreasing its transcriptional activity.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Cycloheximide may block the translocation step in protein synthesis on ribosomes, which could lead to a general decrease in protein synthesis, including the synthesis of Makorin-1.

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$173.00
$418.00
43
(3)

Doxorubicin could intercalate into DNA and block the progression of RNA polymerase II along the MKRN1 gene, leading to a decrease in MKRN1 mRNA synthesis.

ICI 182,780

129453-61-8sc-203435
sc-203435A
1 mg
10 mg
$81.00
$183.00
34
(1)

ICI 182,780 could inhibit the dimerization of estrogen receptors, which may lead to the repression of estrogen-responsive elements within the MKRN1 promoter, resulting in decreased expression of Makorin-1.