Makorin-1 inhibitors are a class of chemical compounds designed to target and inhibit the activity of the Makorin-1 (MKRN1) protein. Makorin-1 is an E3 ubiquitin ligase, meaning it is involved in the process of tagging proteins for degradation via the ubiquitin-proteasome pathway. This protein has several zinc finger domains, which allow it to bind to specific target proteins and regulate their stability by marking them with ubiquitin molecules. Through this mechanism, Makorin-1 plays a critical role in controlling protein turnover and regulating various cellular functions, including transcriptional regulation, RNA processing, and cell cycle control. Inhibitors of Makorin-1 interfere with its ability to ubiquitinate target proteins, thereby affecting the degradation and stability of these proteins within the cell.
The inhibition of Makorin-1 offers valuable insights into the complex regulatory networks involved in maintaining protein homeostasis. By selectively blocking the activity of this E3 ligase, researchers can study the specific roles of proteins that would normally be targeted for degradation, and how their accumulation or altered stability impacts cellular processes. Furthermore, Makorin-1 inhibitors provide a useful tool for understanding the fine-tuned balance between protein synthesis and degradation, especially in pathways that rely on the regulated removal of key proteins. Investigating how cells respond to Makorin-1 inhibition can reveal new details about ubiquitin-mediated regulation and its importance in cellular function, particularly in processes like signal transduction, stress response, and developmental regulation. The use of Makorin-1 inhibitors thus opens up opportunities to explore how disruption of protein turnover influences various biological systems.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could inhibit histone deacetylase activity, leading to hyperacetylation of histones, which may downregulate MKRN1 transcription by altering chromatin accessibility at its gene locus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may decrease methylation of the MKRN1 gene promoter, potentially reducing its transcription by disrupting binding sites for methylation-sensitive transcriptional repressors. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could inhibit the mTOR pathway, which in turn may decrease the initiation of cap-dependent translation, leading to a reduction in Makorin-1 synthesis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may downregulate MKRN1 expression by inhibiting specific kinases involved in the activation of transcription factors that are necessary for MKRN1 gene transcription. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
By inhibiting inosine monophosphate dehydrogenase, mycophenolic acid could lead to a depletion of guanine nucleotides, which may result in the reduced transcription of the MKRN1 gene. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may disrupt endosomal acidification, which could lead to altered intracellular trafficking and lysosomal degradation of MKRN1 mRNA, resulting in decreased levels of Makorin-1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could bind retinoic acid receptors, which may act as transcriptional repressors for the MKRN1 gene, thereby decreasing its transcriptional activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide may block the translocation step in protein synthesis on ribosomes, which could lead to a general decrease in protein synthesis, including the synthesis of Makorin-1. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin could intercalate into DNA and block the progression of RNA polymerase II along the MKRN1 gene, leading to a decrease in MKRN1 mRNA synthesis. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $81.00 $183.00 | 34 | |
ICI 182,780 could inhibit the dimerization of estrogen receptors, which may lead to the repression of estrogen-responsive elements within the MKRN1 promoter, resulting in decreased expression of Makorin-1. |