Date published: 2026-4-1

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MACC1 Inhibitors

MACC1 inhibitors are a class of chemical compounds designed to target and inhibit the activity of the MACC1 (Metastasis Associated in Colon Cancer 1) gene, a regulator known for its role in controlling cell proliferation, migration, and the regulation of key signaling pathways. MACC1 is involved in modulating the hepatocyte growth factor (HGF)/Met signaling pathway, which plays a crucial role in cellular growth, motility, and tissue remodeling. MACC1 has been observed to influence gene expression patterns that contribute to cell communication and intracellular signaling processes. By inhibiting MACC1, researchers can interfere with its role in regulating these cellular mechanisms, providing insights into how it contributes to the modulation of gene expression, cellular growth, and the dynamics of cell migration.

In research, MACC1 inhibitors are valuable tools for exploring the molecular functions of MACC1 and how its inhibition impacts cellular behavior. By blocking MACC1 activity, scientists can study its downstream effects on key cellular pathways, including those related to gene expression, cell-to-cell communication, and the control of cellular movement. This inhibition allows for the investigation of how MACC1 contributes to processes like cell differentiation, tissue repair, and signal transduction, as well as its interactions with other proteins and regulatory molecules. Additionally, MACC1 inhibitors help uncover the broader implications of MACC1 in regulating gene networks and protein interactions within cells, offering researchers a clearer view of its role in cellular homeostasis and function. Through these studies, the use of MACC1 inhibitors enhances our understanding of how genes like MACC1 integrate into the regulatory networks that maintain cell stability and adaptability.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

XL-184 free base

849217-68-1sc-364657
sc-364657A
5 mg
10 mg
$94.00
$208.00
1
(1)

A tyrosine kinase inhibitor targeting MET, VEGFR, and AXL, which can disrupt pathways regulated by MACC1.

PHA 665752

477575-56-7sc-203186
sc-203186A
sc-203186B
sc-203186C
2 mg
10 mg
50 mg
200 mg
$143.00
$281.00
$714.00
$1510.00
24
(1)

A selective inhibitor of the c-Met receptor tyrosine kinase that could impede HGF-induced signaling involved in MACC1's pathway.

Met Kinase Inhibitor

658084-23-2sc-204801
1 mg
$116.00
5
(1)

A selective MET tyrosine kinase inhibitor that might interfere with signaling pathways involving MACC1.

ARQ 197

905854-02-6sc-364408
sc-364408A
50 mg
200 mg
$712.00
$1920.00
(0)

A non-ATP-competitive c-Met inhibitor, potentially influencing the downstream effects of MACC1 activation.

INCB28060

1029712-80-8sc-364510
sc-364510A
10 mg
50 mg
$305.00
$750.00
(0)

A potent and selective c-Met inhibitor that could disrupt MACC1-mediated cellular processes.

JNJ-38877605

943540-75-8sc-364516
sc-364516A
2 mg
10 mg
$126.00
$365.00
1
(0)

A potent and selective small molecule inhibitor of c-Met, potentially affecting MACC1-related signaling.