Date published: 2025-12-5

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M-Ras Inhibitors

M-Ras Inhibitors belong to a class of chemical compounds specifically designed to target the M-Ras protein, a member of the Ras family of small GTPases. Ras proteins are essential components of cell signaling pathways, regulating various cellular processes such as cell growth, differentiation, and survival. M-Ras, in particular, plays a crucial role in modulating these processes, making it a potential target for intervention in cellular activities. The inhibitors belonging to this class are meticulously engineered molecules that interact with the M-Ras protein to disrupt its normal function. These compounds often bind to specific regions on the M-Ras protein, inhibiting its ability to hydrolyze GTP, a process necessary for its activation and subsequent signaling cascades. By interfering with this activation process, M-Ras Inhibitors hinder the downstream signaling pathways associated with M-Ras, thereby disrupting the intricate balance of cellular activities regulated by this protein. The design and development of these inhibitors require a deep understanding of the structural and biochemical properties of M-Ras, allowing medicinal chemists to create compounds that can specifically target M-Ras while minimizing off-target effects. Through advanced computational modeling and experimental validation, researchers aim to refine the chemical structures of M-Ras Inhibitors, enhancing their specificity and potency to ensure effective modulation of M-Ras-related cellular processes. The study of these inhibitors contributes significantly to our understanding of cell signaling mechanisms and holds potential implications for various fields of research and biotechnology.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Farnesyl thiosalicylic acid

162520-00-5sc-205322
sc-205322A
1 mg
5 mg
$60.00
$80.00
15
(1)

Salirasib inhibits M-Ras by interfering with its membrane localization, disrupting downstream signaling.

Manumycin A

52665-74-4sc-200857
sc-200857A
1 mg
5 mg
$215.00
$622.00
5
(1)

Manumycin A inhibits M-Ras by blocking farnesyltransferase, preventing its proper membrane localization.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Sorafenib inhibits M-Ras signaling by targeting multiple kinases in the RAF/MEK/ERK pathway, downstream of M-Ras.

Lonafarnib

193275-84-2sc-482730
sc-482730A
5 mg
10 mg
$173.00
$234.00
(0)

Lonafarnib inhibits M-Ras by inhibiting farnesyltransferase, preventing the farnesylation necessary for membrane association.

Tipifarnib

192185-72-1sc-364637
10 mg
$720.00
(0)

Tipifarnib inhibits M-Ras by disrupting its membrane association through inhibition of farnesyltransferase.

EHT 1864

754240-09-0sc-361175
sc-361175A
10 mg
50 mg
$209.00
$872.00
12
(2)

EHT 1864 inhibits M-Ras by disrupting its membrane localization and impairing downstream signaling.

TAK 632

1228591-30-7sc-473801
5 mg
$224.00
(0)

TAK-632 inhibits M-Ras by targeting the RAF/MEK/ERK pathway, downstream of M-Ras, disrupting its signaling.