Lunapark Activators
Lunapark activators are a class of compounds that enhance the function of Lunapark by directly or indirectly influencing the specific signaling pathways or biological processes that it is involved in. Lunapark activators include compounds like Thapsigargin, Dantrolene, Cyclopiazonic Acid, Ionomycin, Eeyarestatin I, MG132,Salubrinal, Tauroursodeoxycholic Acid, Curcumin, and Geldanamycin. These compounds influence the activity of Lunapark via modulation of calcium homeostasis and protein folding or degradation pathways.
For instance, Thapsigargin, Dantrolene, Cyclopiazonic Acid, and Ionomycin increase the calcium concentration within the ER, and Lunapark's function is enhanced in these calcium-dependent processes. Eeyarestatin I and MG132, on the other hand, inhibit pathways that lead to degradation of proteins, causing an accumulation of proteins within the ER, and hence an increased demand for Lunapark in maintaining ER network stability. Salubrinal, Tauroursodeoxycholic Acid, Curcumin, and Geldanamycin increase the protein folding capacity or enhance the ER stress response mechanisms, leading to an increased demand for ER proteins like Lunapark, thus enhancing its functional activity in maintaining ER network stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an inhibitor of the SERCA pump, which controls the calcium concentration within the ER. An increase in calcium concentration can enhance the function of Lunapark, which is involved in calcium-dependent processes within the ER. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, which control calcium release from the ER. Inhibition of these receptors can increase the calcium concentration within the ER, enhancing the function of Lunapark in calcium-dependent processes. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of the SERCA pump, leading to increased calcium concentration within the ER. Increased calcium levels can enhance the function of Lunapark, which is involved in calcium-dependent processes within the ER. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases the calcium concentration within the ER. Increased calcium levels can enhance the function of Lunapark, which is involved in calcium-dependent processes within the ER. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I inhibits the p97 ATPase and ER-associated degradation (ERAD), leading to an accumulation of proteins within the ER. The increased demand for ER proteins like Lunapark can enhance its functional activity in maintaining ER network stability. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that leads to an accumulation of proteins within the ER. The increased demand for ER proteins like Lunapark can enhance its functional activity in maintaining ER network stability. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal inhibits eIF2α phosphatase, leading to an accumulation of misfolded proteins in the ER. The increased demand for ER proteins like Lunapark can enhance its functional activity in maintaining ER network stability. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic Acid is a bile acid that can increase the protein folding capacity of the ER. This can lead to an increased demand for ER proteins like Lunapark, enhancing its functional activity in maintaining ER network stability. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to enhance ER stress response mechanisms, which can lead to an increased demand for ER proteins like Lunapark, enhancing its functional activity in maintaining ER network stability. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is an inhibitor of Hsp90, a chaperone protein that aids in protein folding in the ER. Inhibition of Hsp90 can lead to an increased demand for ER proteins like Lunapark, enhancing its functional activity in maintaining ER network stability. | ||||||