LRRC49 Activators
LRRC49 Activators encompass a variety of chemical compounds that indirectly enhance the functional activity of LRRC49 through distinct signaling pathways. Forskolin and Isoproterenol, by raising intracellular cAMP levels, facilitate the activation of protein kinase A, which may phosphorylate proteins that interact with LRRC49, leading to its enhanced activity. Similarly, 8-Bromo-cAMP and Dibutyryl cAMP, as cAMP analogs, directly augment cAMP within the cell, thereby activating the same PKA-mediated phosphorylation events that could influence LRRC49 function. Phorbol 12-myristate 13-acetate (PMA) and Bisindolylmaleimide I, through modulation of protein kinase C, provide another avenue for altering signaling cascades that may affect the activity of LRRC49, with PMA activating and Bisindolylmaleimide I inhibiting PKC, thereby reshaping the cellular signaling landscape in a manner that could enhance LRRC49's role.
Additionally, calcium signaling modulators such as Ionomycin, A23187, and FPL 64176 elevate intracellular calcium levels, which in turn activate calcium-dependent kinases and phosphatases, potentially leading to post-translational modifications that enhance LRRC49 activity. Okadaic acid, by inhibiting the action of protein phosphatases PP1 and PP2A, increases the overall phosphorylation state of proteins within the cell, which may indirectly result in the upregulation of LRRC49's activity. Furthermore, Anisomycin as a stress-activated protein kinase activator might lead to changes in the phosphorylation state of signaling molecules that could favor the enhancement of LRRC49 function. Lastly, Oleic acid, through its effects on membrane fluidity and signaling lipid rafts, could modulate the microenvironment of LRRC49, thereby influencing its activity within cellular signaling networks. Together, these compounds act through diverse biochemical mechanisms to enhance the functional activity of LRRC49 without directly altering its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP can lead to the activation of PKA (protein kinase A), which in turn can phosphorylate specific proteins, including those associated with the signaling pathways that LRRC49 is involved in, resulting in its enhanced functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic beta-adrenergic agonist that increases cAMP levels by stimulating adenylyl cyclase. The increase in cAMP activates PKA, which could then phosphorylate proteins that interact with LRRC49 and enhance its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC), which is involved in various signaling cascades. Activation of PKC can lead to downstream signaling events that enhance the functional activity of LRRC49 through phosphorylation of associated proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can trigger calcium-dependent signaling pathways. Such pathways may indirectly enhance the functional activity of LRRC49 by enabling post-translational modifications of the protein or its interacting partners. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that directly increases intracellular cAMP levels, subsequently activating PKA and enhancing the phosphorylation of proteins in pathways associated with LRRC49 activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor that can shift the balance of cellular signaling towards pathways not dependent on PKC. This alteration in signaling dynamics could indirectly enhance the activity of LRRC49 through compensatory mechanisms in the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentrations, similar to ionomycin. This elevation can activate calcium-dependent protein kinases or phosphatases that modulate the activity of proteins associated with LRRC49's functional pathways. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
FPL 64176 is a calcium channel agonist that increases intracellular calcium levels. This agonist could enhance LRRC49 activity by stimulating calcium-dependent signaling cascades that interact with the protein or its related pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is another cAMP analog that penetrates cells and raises cAMP levels, thus activating PKA and potentially enhancing the phosphorylation state of proteins involved in pathways where LRRC49 plays a role. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This can indirectly enhance the activity of LRRC49 by altering the phosphorylation state of proteins within its associated signaling pathways. | ||||||