LRFN5 Inhibitors
LRFN5 Inhibitors exhibit a variety of mechanisms that lead to the inhibition of this particular protein's functional activity in neurons, especially its role in synaptic plasticity and development. Certain inhibitors function by engaging with receptors or channels to suppress excitatory neurotransmission, thereby indirectly diminishing the synaptic interactions where LRFN5 is vital. For instance, compounds that block voltage-gated sodium or calcium channels prevent the propagation of action potentials or decrease excitatory neurotransmitter release, which can attenuate the LRFN5-mediated modulation of synapses. Furthermore, substances that modulate the activity of the NMDA receptor or TRPM7 channels by either potentiating or inhibiting them could influence LRFN5's role in synaptic transmission, either by altering glutamatergic activity or by impacting neuronal excitability and plasticity.
Additionally, there are inhibitors that exert their effects by binding to specific subunits of ion channels or engaging with intracellular signaling pathways, thus impacting the synaptic functions associated with LRFN5. For example, agents that act as agonists at GABA receptors or PPAR-α induce an inhibitory effect on synaptic activity, which is likely to affect the plasticity and development of synapses where LRFN5 is functionally important. Moreover, inhibitors that target the downstream signaling pathways of LRFN5 can affect its role in synaptogenesis and neuronal communication. For example, if LRFN5 is involved in pathways that include kinases like CaMKII or protein phosphatases such as calcineurin, then inhibitors targeting these enzymes could indirectly regulate the function of LRFN5 by altering its phosphorylation state or the phosphorylation state of proteins that interact with LRFN5.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $78.00 $238.00 $2050.00 $3274.00 $16330.00 | ||
An endogenous fatty acid amide that engages with peroxisome proliferator-activated receptor alpha (PPAR-α). Activation of PPAR-α leads to a response which can suppress the synaptic plasticity mediated by LRFN5 in neuronal cells. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
Acts as a potent blocker of the transient receptor potential melastatin 7 (TRPM7) channel. LRFN5 plays a crucial role in synapse development, and the inhibition of TRPM7 channels can alter neuronal excitability and synaptic transmission, thus affecting LRFN5's functional role. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
A glutamate antagonist that inhibits glutamatergic transmission. Since LRFN5 is involved in the modulation of synapses, the reduced glutamatergic activity can lead to the attenuation of LRFN5-mediated synaptic functions. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
An analog of the neurotransmitter GABA that binds to the α2δ subunit of voltage-gated calcium channels, decreasing excitatory neurotransmitter release. This action could dampen the synaptic activity where LRFN5 is functionally important. | ||||||
(±)-Baclofen | 1134-47-0 | sc-200464 sc-200464A | 1 g 5 g | $55.00 $253.00 | ||
A GABA B receptor agonist that inhibits the release of excitatory neurotransmitters. LRFN5 modulates synapse function, and the activation of GABA B receptors can reduce neurotransmitter release, potentially diminishing the role of LRFN5 in synaptic plasticity. | ||||||
D-Cycloserine | 68-41-7 | sc-221470 sc-221470A sc-221470B sc-221470C | 200 mg 1 g 5 g 25 g | $27.00 $75.00 $139.00 $520.00 | 4 | |
A partial agonist at the glycine site of the NMDA receptor, which can potentiate or inhibit NMDA receptor activity. By modulating NMDA receptors, it may indirectly influence the synaptic interactions mediated by LRFN5. | ||||||
Apamin | 24345-16-2 | sc-200994 sc-200994A | 500 µg 1 mg | $168.00 $280.00 | 7 | |
Blocks small conductance calcium-activated potassium (SK) channels. Inhibition of SK channels can modulate neuronal firing patterns and synaptic plasticity, consequently impacting LRFN5-dependent synaptic activity. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
An agonist of glutamate-gated chloride channels that causes hyperpolarization and reduced neuronal activity. By modulating these channels, ivermectin can impact synaptic functions where LRFN5 is involved. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $32.00 $70.00 | 5 | |
Blocks voltage-gated sodium channels, which can attenuate synaptic transmission and excitability. This might indirectly reduce LRFN5-mediated modulation of synaptic function. | ||||||