LPAAT-ζ Activators
The bioactive lipid, Lysophosphatidic acid (LPA), plays a pivotal role as a substrate for LPAAT-ζ, underlining its significance in the enzyme's catalytic mechanism. The presence of LPA within the cellular milieu is essential for the enzymatic action of LPAAT-ζ, as it provides the necessary substrate for the acylation process, leading to the formation of phosphatidic acid-a crucial intermediate in the biosynthesis of phospholipids. Compounds like Arachidonic Acid and Oleic Acid also serve as acyl donors for the LPAAT-ζ catalyzed reaction, directly contributing to the enzyme's functional activity by offering required substrates for the creation of phosphatidic acid.
On the other hand, certain compounds may indirectly influence LPAAT-ζ activity by modulating lipid signaling pathways or altering membrane dynamics. For instance, Sphingosine 1-phosphate (S1P),, can initiate receptor-mediated signaling cascades that increase the production of lysophosphatidic acid, thus potentially boosting LPAAT-ζ activity by augmenting substrate availability. Similarly, Phosphatidylinositol 4,5-bisphosphate (PIP2) acts as a cofactor in cellular signaling, potentially enhancing LPAAT-ζ activity by modulating pathways that govern lipid biosynthesis, including those enzymes that function upstream of LPAAT-ζ.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA is a substrate for LPAAT-ζ, and its presence in the cellular environment is crucial for the enzymatic activity of LPAAT-ζ. By providing substrate availability, LPA directly enhances LPAAT-ζ's ability to acylate lysophosphatidic acid to form phosphatidic acid, a key step in phospholipid biosynthesis. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P can act as a bioactive lipid that, through its receptor-mediated actions, can lead to intracellular signaling cascades that enhance the synthesis of lysophosphatidic acid, thus indirectly enhancing LPAAT-ζ activity by increasing its substrate availability. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
As a fatty acid, arachidonic acid can serve as an acyl donor in the LPAAT-ζ catalyzed reaction, thereby directly enhancing the enzyme's functional activity by providing necessary substrates for the biosynthesis of phosphatidic acid. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Phosphatidylserine can influence membrane curvature and lipid packing, which can indirectly enhance LPAAT-ζ activity by altering membrane microenvironments conducive to the enzyme's optimal activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid, as a monounsaturated fatty acid, is another acyl donor in the LPAAT-ζ reaction, and its presence can enhance the enzyme's activity by providing the necessary components for the production of phosphatidic acid. | ||||||
Glycerophosphoric acid | 57-03-4 | sc-353615 sc-353615A | 5 g 25 g | $311.00 $872.00 | ||
Glycerol 3-phosphate is a precursor in the synthesis of glycerophospholipids and can enhance LPAAT-ζ activity indirectly by increasing the availability of the backbone structure for phosphatidic acid synthesis. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $32.00 $36.00 $51.00 | 1 | |
Choline chloride can enhance LPAAT-ζ activity indirectly by participating in the CDP-choline pathway for phosphatidylcholine synthesis, which is interconnected with the pathways involving phosphatidic acid, the product of LPAAT-ζ. | ||||||
myo-Inositol | 87-89-8 | sc-202714 sc-202714A sc-202714B sc-202714C | 100 g 250 g 1 kg 5 kg | $78.00 $148.00 $270.00 $821.00 | ||
Myo-inositol is a component of the phosphatidylinositol signaling pathway and can indirectly enhance LPAAT-ζ activity by influencing the demand for phosphatidic acid in the synthesis of phosphatidylinositols. | ||||||