LPAAT-δ Activators

LPAAT-δ Activators represent a group of chemicals that can influence the activation of LPAAT-δ, also known as AGPAT4, a key enzyme involved in phospholipid synthesis. Insulin, a regulator of lipid metabolism, can enhance lipid synthesis, possibly leading to a greater demand for AGPAT4 activity. Metformin, an activator of AMPK, can introduce changes in lipid synthesis pathways, thus having an indirect effect on AGPAT4.

Agents like rosiglitazone, pioglitazone, and troglitazone, all PPARγ agonists, regulate lipid storage and metabolism, which can indirectly affect AGPAT4-related processes. Similarly, fenofibrate, as a PPARα agonist, affects fatty acid oxidation, which in turn can modulate AGPAT4's role in lipid synthesis. L-carnitine, crucial for fatty acid transport into mitochondria, can affect fatty acid availability, influencing AGPAT4's lipid synthesis role. Other chemicals like Coenzyme Q10, with its pivotal role in the electron transport chain, and berberine, an AMPK activator, also play roles in lipid metabolism, which can influence AGPAT4's activity.