LOXL1 Activators
The chemical class of LOXL1 activators encompasses a diverse array of compounds that exert their stimulatory effects through intricate interactions with specific cellular signaling pathways. Astaxanthin, for instance, acts as an activator by enhancing the Nrf2/ARE signaling pathway. It facilitates Nrf2 translocation and activation, leading to increased binding to the antioxidant response element (ARE) in the LOXL1 promoter region. Betulinic acid functions as a LOXL1 activator by modulating the Hedgehog signaling pathway. It promotes Hedgehog pathway activity, leading to enhanced expression of LOXL1. Similarly, carnosic acid serves as a LOXL1 activator through its influence on the JAK/STAT signaling pathway. It enhances JAK activation, leading to increased STAT-mediated transcription of LOXL1, resulting in the upregulation of LOXL1 expression and modulation of its function in extracellular matrix remodeling processes. Celastrol, another activator, targets the mTOR signaling pathway. It promotes mTOR activation, leading to enhanced LOXL1 gene expression. Dioscin, functioning as a LOXL1 activator through the AMPK signaling pathway, activates AMPK, leading to increased downstream effects that include enhanced LOXL1 gene expression. Ellipticine, a LOXL1 activator, modulates the Wnt/β-catenin signaling pathway, promoting β-catenin nuclear translocation and leading to increased transcriptional activation of LOXL1. Ginkgolide A, an activator, influences the Hippo signaling pathway, promoting Hippo pathway activity and enhancing the expression of LOXL1.
Glycyrrhizic acid acts as a LOXL1 activator through its impact on the PI3K/Akt signaling pathway. It enhances Akt phosphorylation, leading to increased downstream activation of transcription factors involved in LOXL1 gene expression. Kaempferol, functioning as a LOXL1 activator, modulates the MAPK/ERK signaling pathway, enhancing the phosphorylation cascade and leading to increased transcriptional activation of LOXL1. Oleanolic acid serves as a LOXL1 activator through its influence on the Notch signaling pathway. Piperine, another activator, targets the TGF-β signaling pathway. It enhances Smad protein phosphorylation, leading to increased transcriptional activation of LOXL1. Lastly, Ursolic acid, distinct from its inhibitory role, also functions as a LOXL1 activator by influencing the Nrf2/ARE signaling pathway. It enhances Nrf2 translocation and activation, leading to increased binding to the antioxidant response element (ARE) in the LOXL1 promoter region.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid functions as a LOXL1 activator by modulating the Hedgehog signaling pathway. It promotes Hedgehog pathway activity, leading to enhanced expression of LOXL1. The activation of this pathway by betulinic acid provides a mechanism for upregulating LOXL1 levels and augmenting its function in extracellular matrix dynamics. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $60.00 $165.00 | 6 | |
Carnosic acid acts as a LOXL1 activator through its influence on the JAK/STAT signaling pathway. It enhances JAK activation, leading to increased STAT-mediated transcription of LOXL1. The upregulation of LOXL1 expression induced by carnosic acid contributes to the activation of LOXL1 in extracellular matrix remodeling processes. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol serves as a LOXL1 activator by targeting the mTOR signaling pathway. It promotes mTOR activation, leading to enhanced LOXL1 gene expression. The activation of mTOR by celastrol provides a mechanism for upregulating LOXL1 levels and modulating its function in extracellular matrix dynamics. | ||||||
Dioscin | 19057-60-4 | sc-497470 | 25 mg | $380.00 | ||
Dioscin functions as a LOXL1 activator through its impact on the AMPK signaling pathway. It activates AMPK, leading to increased downstream effects that include enhanced LOXL1 gene expression. The activation of AMPK by dioscin provides a mechanism for upregulating LOXL1 levels and influencing its function in extracellular matrix remodeling processes. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine acts as a LOXL1 activator by modulating the Wnt/β-catenin signaling pathway. It promotes β-catenin nuclear translocation, leading to increased transcriptional activation of LOXL1. The activation of the Wnt/β-catenin pathway by ellipticine provides a mechanism for upregulating LOXL1 levels and modulating its function in extracellular matrix dynamics. | ||||||
Ginkgolide A | 15291-75-5 | sc-205705 sc-205705A sc-205705B sc-205705D sc-205705C | 10 mg 25 mg 250 mg 1 g 500 g | $67.00 $159.00 $406.00 $1108.00 $679.00 | 2 | |
Ginkgolide A serves as a LOXL1 activator by influencing the Hippo signaling pathway. It promotes Hippo pathway activity, leading to enhanced expression of LOXL1. The activation of this pathway by ginkgolide A provides a mechanism for upregulating LOXL1 levels and modulating its function in extracellular matrix dynamics. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $56.00 $326.00 | 7 | |
Glycyrrhizic acid acts as a LOXL1 activator through its impact on the PI3K/Akt signaling pathway. It enhances Akt phosphorylation, leading to increased downstream activation of transcription factors involved in LOXL1 gene expression. The activation of PI3K/Akt signaling by glycyrrhizic acid provides a mechanism for upregulating LOXL1 levels and influencing its function in extracellular matrix remodeling processes. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol functions as a LOXL1 activator by modulating the MAPK/ERK signaling pathway. It enhances the phosphorylation cascade in this pathway, leading to increased transcriptional activation of LOXL1. The activation of MAPK/ERK signaling by kaempferol provides a mechanism for upregulating LOXL1 levels and modulating its function in extracellular matrix dynamics. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
Oleanolic acid serves as a LOXL1 activator through its influence on the Notch signaling pathway. It enhances Notch receptor cleavage and activation, leading to increased downstream effects that include enhanced LOXL1 gene expression. The activation of Notch signaling by oleanolic acid provides a mechanism for upregulating LOXL1 levels and influencing its function in extracellular matrix remodeling processes. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine acts as a LOXL1 activator by targeting the TGF-β signaling pathway. It enhances Smad protein phosphorylation, leading to increased transcriptional activation of LOXL1. The activation of the TGF-β pathway by piperine provides a mechanism for upregulating LOXL1 levels and modulating its function in extracellular matrix dynamics. | ||||||