LOC666145 Activators
Armadillo-like helical domain containing 2 (LOC666145) Activators represent a diverse group of chemical compounds that indirectly influence the activity of LOC666145 through various biochemical pathways. Forskolin, for instance, boosts intracellular cAMP levels, leading to PKA activation. This activation has downstream effects on pathways involving LOC666145, potentially enhancing its activity via phosphorylation of pathway components or altering protein-protein interactions. Similarly, Epigallocatechin gallate (EGCG), known for its antioxidant properties, modulates oxidative stress pathways. Since LOC666145 is responsive to cellular stress, EGCG may indirectly enhance its activity. Sphingosine-1-phosphate and Thapsigargin also play significant roles; S1P influences LOC666145 through its effects on MAPK and PI3K/Akt pathways, while Thapsigargin raises intracellular calcium levels, activating calcium-dependent pathways that could include LOC666145.
Moreover, the involvement of PI3K inhibitors like LY294002 and Wortmannin adds another dimension. By inhibiting PI3K, these compounds potentially alter the dynamics of pathways where LOC666145 is active, leading to its indirect activation. This effect is mirrored by MEK inhibitors (PD98059 and U0126), which shift signaling equilibrium, possibly enhancing LOC666145's role. Staurosporine's broad-spectrum kinase inhibition might remove inhibitory controls on LOC666145, leading to its activation. Additionally, PMA activates PKC, impacting pathways that intersect with those of LOC666145, while A23187, a calcium ionophore, enhances LOC666145 activity through calcium-dependent signaling. Lastly, Genistein's inhibition of tyrosine kinases may alter pathways involving LOC666145, enhancing its activity. Collectively, these activators, through their targeted influence on cellular signaling, facilitate the enhancement of LOC666145 functions without necessitating direct activation or upregulation of its expression.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, as a known antioxidant, can modulate signaling pathways related to oxidative stress. LOC666145, being sensitive to cellular stress responses, could be indirectly activated by EGCG's modulation of these pathways, enhancing its activity in response to altered cellular environments. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) engages with its receptors to activate signaling cascades that include MAPK and PI3K/Akt pathways. These pathways can intersect with those involving LOC666145, potentially enhancing its activity through cross-talk or synergistic effects on common downstream targets. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). Elevated calcium levels can activate calcium-dependent signaling pathways, which may include those involving LOC666145, thereby indirectly enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it can shift cellular signaling dynamics, potentially impacting pathways where LOC666145 is active. This could lead to a compensatory enhancement of LOC666145's activity in response to altered PI3K signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, another PI3K inhibitor, works similarly to LY294002. It may lead to changes in signaling pathways that intersect with those of LOC666145, indirectly enhancing its functional activity by altering the cellular signaling landscape. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK pathway. By inhibiting MEK, PD98059 could indirectly influence pathways that involve LOC666145, potentially leading to its enhanced activation through altered pathway dynamics. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor. Its action could lead to an indirect enhancement of LOC666145 activity by shifting the balance of signaling in pathways where LOC666145 operates, promoting its functional role. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. Its inhibition of certain kinases could remove negative regulatory influences on LOC666145, potentially leading to its enhanced activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which can modulate various signaling pathways. This activation may enhance LOC666145's activity indirectly by influencing pathways or proteins that interact with or regulate LOC666145. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium levels, which can activate calcium-dependent pathways. These pathways may interact with or influence those involving LOC666145, leading to its enhanced activity. | ||||||