LOC644222 Inhibitors
LOC644222 inhibitors encompass a group of chemical compounds that function through various cellular mechanisms to reduce the activity of LOC644222. Staurosporine, a broad kinase inhibitor, can prevent the phosphorylation of proteins by inhibiting PKC, which may be necessary for the functional activity of LOC644222. Inhibition of PI3K by LY294002 leads to reduced Akt phosphorylation, which is a crucial step in multiple signaling pathways; if LOC644222 is Akt-dependent, then its activity would be compromised. Similarly, PP2's inhibition of Src family kinases could reduce LOC644222 activity if it relies on Src signaling for activation.
The inhibition of the mTOR pathway by rapamycin could lead to a decrease in LOC644222 activity if it is involved in processes regulated by mTORC1. The MAPK pathway, known to be involved in numerous cellular functions, can be inhibited by PD98059 and U0126, which target MEK, leading to reduced ERK activation. If LOC644222 is dependent on ERK signaling, these inhibitors would lead to decreased LOC644222 activity. SP600125 and SB203580 specifically inhibit JNK and p38 MAPK, respectively, which could reduce LOC644222 activity if it functions downstream of these kinases.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor with broad specificity, staurosporine inhibits protein kinase C (PKC), which could lead to reduced phosphorylation of downstream proteins that may be necessary for LOC644222 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
An inhibitor of PI3K, LY294002 would lead to a decrease in Akt phosphorylation. As Akt can phosphorylate various substrates, inhibiting this pathway may reduce the phosphorylation and activation of LOC644222 if it is Akt-dependent. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor, PP2 could diminish LOC644222 activity if LOC644222 is activated by Src kinase signaling, by preventing Src-induced phosphorylation that might be critical for LOC644222 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, rapamycin could suppress LOC644222 if LOC644222 is involved in cell growth and proliferation pathways regulated by mTORC1 signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK, PD98059 could decrease ERK pathway signaling. If LOC644222 is regulated via the ERK pathway, its activity would be reduced by preventing ERK phosphorylation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK, SP600125 could lead to diminished LOC644222 activity if LOC644222 functions downstream of JNK signaling by inhibiting JNK-mediated phosphorylation events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
An inhibitor of p38 MAPK, SB203580 could inhibit LOC644222 activity by preventing p38 MAPK-mediated signaling events that may be critical for LOC644222 activation. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A BCR-ABL and Src family kinase inhibitor, dasatinib could reduce LOC644222 activation if LOC644222 is associated with BCR-ABL or Src family kinase signaling pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, bortezomib could lead to the accumulation of proteins that negatively regulate LOC644222, thus indirectly inhibiting its activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A PKC inhibitor, Go6983 could decrease LOC644222 activity if LOC644222 is activated downstream of PKC by preventing PKC-mediated phosphorylation. | ||||||