LOC644070 Activators

A-769662 and Rolipram exert their influence by modulating AMPK and PDE4 respectively, both of which are involved in the regulation of cAMP, a second messenger with broad implications for protein function. SB 216763 and GSK-3 Inhibitor IX can affect the Wnt/β-catenin signaling pathway by acting on GSK-3β, influencing the activity of proteins involved in cell growth and differentiation. Y-27632's inhibition of ROCK can impact proteins associated with the cytoskeleton and cell motility, while BIX 01294's targeting of histone methyltransferases can alter gene expression profiles, affecting protein levels indirectly. PD0325901 and Puerarin can modulate the MAPK/ERK and PI3K/Akt signaling pathways respectively, influencing the function of a variety of proteins regulated by these pathways.

ZM-447439's action on Aurora kinase affects proteins involved in cell division, and LY294002's inhibition of PI3K influences downstream protein activity in cell survival and proliferation. MG132, by inhibiting the proteasome, can lead to the accumulation of proteins that are normally targeted for degradation, potentially increasing the activity of those proteins. SP600125, through JNK inhibition, can modulate proteins implicated in stress responses and apoptosis.