LOC643933 Activators

Forskolin and IBMX raise the levels of cAMP, a second messenger with extensive roles in cellular signaling, thereby affecting the functional state of proteins responsive to cAMP. Genistein and PD98059, by interfering with tyrosine kinase signaling and MEK activity respectively, have the potential to alter the activity of proteins within those pathways.

LY294002 and Wortmannin serve as PI3K inhibitors, disrupting a key pathway involved in regulating cell growth and survival, which can have wide-ranging implications for proteins downstream of PI3K/Akt signaling. U0126 and SB203580, by inhibiting MEK and p38 MAPK respectively, can induce changes in proteins that are regulated by the MAPK/ERK and p38 MAPK pathways, which are critical in controlling cell differentiation, proliferation, and response to stress. Rapamycin's inhibition of mTOR signaling can affect protein synthesis and autophagy, thereby modulating proteins involved in cellular metabolism and growth. KN-93, by targeting CaMKII, can influence proteins that are regulated by calcium/calmodulin-dependent processes. NF449's selective inhibition of the Gsα-subunit of G-proteins can impact proteins that are regulated by G-protein-coupled receptor signaling.