LOC391356 Activators
Chemical activators of LOC391356 employ various cellular mechanisms to modulate the activity of this protein. Calcium ionophore A23187, for instance, directly raises the intracellular calcium concentration, which activates calcium-dependent protein kinases that are capable of phosphorylating LOC391356, leading to its activation. Similar in function, Ionomycin is another calcium ionophore that increases intracellular calcium levels, thereby activating calcium/calmodulin-dependent protein kinases (CaMKs) that can also target LOC391356 for phosphorylation. Thapsigargin operates by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), causing a rise in cytosolic calcium levels, which can activate similar calcium-dependent kinases to phosphorylate and activate LOC391356.
Additionally, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate LOC391356. Forskolin raises cAMP levels, leading to the activation of PKA (cAMP-dependent protein kinase), which can phosphorylate LOC391356. Dibutyryl-cAMP (db-cAMP) is a cAMP analog that activates PKA, which in turn can phosphorylate LOC391356. Jasplakinolide activates the RhoA-associated kinase (ROCK), which may activate downstream kinases that phosphorylate LOC391356. Okadaic acid and Calyculin A are inhibitors of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins, such as LOC391356, by preventing their dephosphorylation. Anisomycin activates MAP kinase pathways which can lead to the phosphorylation of LOC391356. Lastly, Epigallocatechin gallate (EGCG) inhibits phosphodiesterases, increasing cAMP levels and activating PKA, which may target LOC391356 for phosphorylation. Each of these chemicals engages distinct molecular pathways to influence the phosphorylation state and consequent activation of LOC391356.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 directly increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases can, in turn, phosphorylate LOC391356, leading to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate an array of proteins. LOC391356, being a protein, can be functionally activated through phosphorylation mediated by PKC. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, which activates calcium/calmodulin-dependent protein kinases (CaMKs). CaMKs could target LOC391356, resulting in its activation through phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA can phosphorylate and thus activate LOC391356. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can activate RhoA-associated kinase (ROCK), which in turn can activate downstream kinases that may phosphorylate and activate LOC391356. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. Inhibition of these phosphatases can prevent the dephosphorylation of LOC391356, maintaining it in an activated state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates MAP kinase pathways, which could lead to the activation of LOC391356 through phosphorylation by MAP kinases. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), causing a rise in cytosolic calcium levels, which can activate calcium-dependent kinases that could phosphorylate and activate LOC391356. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits phosphodiesterases, which leads to increased cAMP levels and subsequent activation of PKA. PKA may phosphorylate LOC391356, resulting in activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatase 1 and 2A, similar to Okadaic acid, leading to increased phosphorylation of proteins. This could maintain LOC391356 in a phosphorylated and active state. | ||||||