LOC198437 Inhibitors
LKAAEAR motif containing 1, abbreviated as LKAAEAR1, is a protein defined by the presence of a specific amino acid sequence motif, the LKAAEAR motif. This sequence is a signature motif that may be involved in protein-protein interactions, localization, or function within the cell. The exact function of LKAAEAR1 is not widely characterized, but the presence of such a motif hints at its potential roles in cellular processes.
Motifs like LKAAEAR are often indicative of a protein's role in signaling pathways or as part of a complex that regulates gene expression, protein stability, or cellular localization. Proteins with unique motifs can serve as docking sites for other proteins, facilitating the assembly of multiprotein complexes, which are crucial in the regulation of diverse cellular functions.The amino acid sequence represented by "LKAAEAR" includes both hydrophobic (leucine, alanine) and charged (lysine, glutamic acid, arginine) residues, suggesting that the motif might be involved in interactions that are sensitive to the conformational state of the protein or the cellular environment, such as changes in pH or the presence of other interacting molecules.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), potentially reducing expression of genes by increasing chromatin condensation and thus decreasing transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA and RNA, inhibits DNA methyltransferases, potentially leading to demethylation and activation of silenced genes, indirectly affecting protein expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and prevents RNA synthesis by inhibiting RNA polymerase, thus blocking gene expression at the transcriptional level. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II, leading to the inhibition of mRNA synthesis and potentially reducing protein expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in protein synthesis; downregulation of mTOR activity can result in reduced protein translation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin causes premature chain termination during translation by acting as an analog of aminoacyl-tRNA, thus inhibiting protein synthesis. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to depletion of guanosine nucleotides and potentially impairing mRNA synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin interferes with peptide bond formation on ribosomes, inhibiting protein synthesis at the level of translation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II-dependent transcription elongation, thus potentially reducing gene expression. | ||||||