LOC120824 Inhibitors
LOC120824 inhibitors include a variety of chemical compounds that interfere with specific cellular signaling pathways and biological processes, which would logically lead to the inhibition of LOC120824's activity. Staurosporine, as a broad-spectrum protein kinase inhibitor, can dampen multiple kinase-dependent signaling cascades. Since the phosphorylation state of proteins is often pivotal for their function, if LOC120824 activity depends on kinase-mediated phosphorylation, staurosporine could cause its inhibition. Similarly, LY294002 and Wortmannin are inhibitors of PI3K, which is upstream of the AKT pathway-a critical pathway for numerous cellular functions. If LOC120824's activity is contingent on PI3K/AKT signaling, these inhibitors would logically lead to a reduction in LOC120824's activity.
Further, Rapamycin and other mTOR inhibitors like it selectively target the mTORC1 complex. If LOC120824 functions downstream of, or is regulated by, the mTORC1 complex, Rapamycin would inhibit its activity. MEK inhibitors such as PD98059 and U0126 block the MAPK/ERK pathway. If LOC120824 is a downstream effector within this pathway, its functional activity would be decreased. SB203580 and SP600125 are inhibitors of p38 MAPK and JNK, respectively. If LOC120824's activity is governed by either of these pathways, these inhibitors can abrogate its activity. Brefeldin A disrupts protein trafficking, which could interfere with the functionality of LOC120824 if proper localization is essential for its action. Energy metabolism is also a target for inhibition, with 2-Deoxy-D-glucose impairing glycolysis and potentially reducing available ATP.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Protein kinase inhibitor that broadly targets various kinase-dependent signaling pathways. LOC120824, if it relies on phosphorylation events mediated by kinases, would have its functional activity decreased due to the broad inhibition of kinase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that prevents the phosphorylation of PIP2 to PIP3, crucial for AKT pathway activation. If LOC120824 is functionally dependent on the PI3K/AKT signaling for activation, its activity would be inhibited. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Selective mTOR inhibitor that specifically inhibits mTORC1 complex. If LOC120824 function is linked to mTORC1 signaling, rapamycin would lead to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Potent PI3K inhibitor that prevents the activation of the AKT pathway. If LOC120824's activity is regulated through PI3K/AKT signaling, wortmannin would diminish its functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that blocks the MAPK/ERK pathway, which, if LOC120824 is a downstream effector, would lead to a decrease in its functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that impedes the activity of proteins regulated by the p38 MAPK signaling. If LOC120824 requires p38 MAPK activity for its function, this inhibitor would decrease its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that would inhibit the activation of proteins involved in JNK signaling. If LOC120824 is modulated by JNK pathway activity, this inhibitor would lead to a reduction in its functional activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibitor of MEK1/2, preventing the activation of ERK1/2. If LOC120824 relies on the MAPK/ERK pathway, U0126 would result in the suppression of its functional activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Inhibitor of ADP-ribosylation factor, disrupting protein trafficking. If LOC120824's function requires correct localization, Brefeldin A would impair its functional activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Inhibitor of glycolysis which may lead to reduced ATP levels, thus potentially inhibiting proteins like LOC120824 if their function is ATP-dependent. | ||||||