LOC100041389 Inhibitors

LOC100041389 inhibitors like LY294002 and Wortmannin target the PI3K/Akt pathway, essential for regulating cell growth and survival. Inhibition of this pathway may lead to changes in the phosphorylation state of various proteins and alter their function. Rapamycin, an mTOR inhibitor, affects protein synthesis and degradation, which can impact the stability and activity of many proteins.

SB203580 and PD98059 target the MAP kinase pathways which are crucial in mediating cellular responses to stress and inflammation. By inhibiting these pathways, SB203580 and PD98059 could reduce the activation of proteins that rely on MAP kinase signaling for their activity. MG132 and Z-VAD-FMK work to prevent protein degradation, either through ubiquitin-proteasome system inhibition or by blocking apoptosis, respectively. This action results in an increase in the cellular level of various proteins, potentially affecting their function. Compounds such as Cycloheximide halt protein synthesis, leading to a decrease in the overall protein content within a cell. This broad action can significantly impact cellular function and protein expression. U0126 and KN-93 affect the MAPK/ERK and CaMKII pathways, respectively, leading to changes.