LOC100041389 Inhibitors
LOC100041389 inhibitors like LY294002 and Wortmannin target the PI3K/Akt pathway, essential for regulating cell growth and survival. Inhibition of this pathway may lead to changes in the phosphorylation state of various proteins and alter their function. Rapamycin, an mTOR inhibitor, affects protein synthesis and degradation, which can impact the stability and activity of many proteins.
SB203580 and PD98059 target the MAP kinase pathways which are crucial in mediating cellular responses to stress and inflammation. By inhibiting these pathways, SB203580 and PD98059 could reduce the activation of proteins that rely on MAP kinase signaling for their activity. MG132 and Z-VAD-FMK work to prevent protein degradation, either through ubiquitin-proteasome system inhibition or by blocking apoptosis, respectively. This action results in an increase in the cellular level of various proteins, potentially affecting their function. Compounds such as Cycloheximide halt protein synthesis, leading to a decrease in the overall protein content within a cell. This broad action can significantly impact cellular function and protein expression. U0126 and KN-93 affect the MAPK/ERK and CaMKII pathways, respectively, leading to changes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), LY294002 can downregulate PI3K/Akt signaling pathway potentially affecting proteins regulated by this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, Rapamycin can suppress the mTOR pathway which may influence protein synthesis and degradation, affecting the stability of various proteins. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAP kinase inhibitor, SB203580 can modulate inflammatory responses and cell cycle, potentially altering the activity of proteins involved in these processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A specific inhibitor of MEK, PD98059 can block the MAPK/ERK pathway, which may affect the phosphorylation state and function of certain proteins. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of the c-Jun N-terminal kinase (JNK), SP600125 can alter signal transduction and affect protein activities linked to the JNK pathway. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor, MG132 can prevent the degradation of ubiquitinated proteins, potentially influencing the levels and function of various proteins. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
An inhibitor of protein biosynthesis in eukaryotic organisms, Cycloheximide can lead to reduced protein levels by blocking translation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor, Wortmannin can also affect the PI3K/Akt pathway, potentially altering the function of proteins regulated by this pathway. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
A pan-caspase inhibitor, Z-VAD-FMK can prevent apoptosis, potentially affecting the levels and activity of proteins that are involved in apoptotic processes. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
An inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII), KN-93 can affect signaling pathways that involve CaMKII, influencing various protein functions. | ||||||