Liprin α2 Inhibitors
Chemical inhibitors of Liprin α2 target various aspects of cellular signaling and cytoskeletal dynamics to inhibit the protein's function. SU6656, a selective Src family kinase inhibitor, disrupts the signaling cascade required for Liprin α2's role in focal adhesion turnover. PF-573228 acts similarly by selectively inhibiting focal adhesion kinase (FAK), which is also involved in cellular adhesion and migration processes that Liprin α2 regulates. CK-636, by inhibiting the Arp2/3 complex, impedes actin network formation and thus Liprin α2's role in actin cytoskeletal organization. ML-7 targets the phosphorylation process of myosin light chains by inhibiting myosin light chain kinase (MLCK), crucial for actin-myosin contraction, subsequently impairing Liprin α2-associated cytoskeletal dynamics and cell motility.
Y-27632, which selectively inhibits the Rho-associated protein kinase (ROCK), can disrupt actin cytoskeleton assembly, a process in which Liprin α2 is implicated, especially in the assembly of presynaptic active zones. PP2 also targets Src family tyrosine kinases, affecting neuronal signaling pathways where Liprin α2 is involved. Actin disruption is further achieved by Latrunculin A and Cytochalasin D, which prevent actin polymerization by binding to monomeric G-actin and the barbed ends of actin filaments, respectively, inhibiting the synaptic organizing function of Liprin α2. On the microtubule end, Colchicine, Nocodazole, and Paclitaxel alter microtubule dynamics by either inhibiting polymerization or hyperstabilizing microtubules, thereby inhibiting Liprin α2's regulatory function in neuronal function and organization. Each chemical, through its unique mechanism, contributes to the collective inhibition of Liprin α2's role in cell structure and signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $57.00 $133.00 | 27 | |
SU6656 is a selective Src family kinase inhibitor. Liprin α2 is known to be involved in the regulation of focal adhesions, and Src family kinases play a crucial role in this process. By inhibiting these kinases, SU6656 can disrupt the signaling cascade required for the proper function of Liprin α2 in focal adhesion turnover. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is an inhibitor of myosin II ATPase activity. Given that Liprin α2 has been implicated in the regulation of cytoskeletal dynamics, inhibiting myosin II can impair the contractility and tension of the cytoskeleton, thereby inhibiting the functions of Liprin α2 in cytoskeletal organization. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). MLCK phosphorylates myosin light chains, which is critical for actin-myosin contraction. Liprin α2, being associated with cytoskeletal regulation, can be functionally inhibited by ML-7 through the disruption of cytoskeletal dynamics and cell motility. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK). ROCK is involved in regulating actin cytoskeleton assembly, and Liprin α2 is implicated in the assembly of presynaptic active zones, which requires an intact actin cytoskeleton. Y-27632 can therefore inhibit the function of Liprin α2 by disrupting actin cytoskeleton dynamics. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Since Liprin α2 has been associated with processes that are regulated by Src kinases, such as neuronal signaling, PP2 can inhibit Liprin α2's function by inhibiting Src kinase activity, thereby disrupting downstream signaling pathways. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to monomeric G-actin, preventing its polymerization into F-actin. Liprin α2's role in synapse assembly is closely linked to actin dynamics; therefore, by destabilizing the actin cytoskeleton, Latrunculin A can inhibit the synaptic organizing function of Liprin α2. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation. This action can inhibit Liprin α2's role in actin filament formation and maintenance, which is essential for its role in presynaptic development and maintenance. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules. Liprin α2 is involved in the regulation of microtubule dynamics; therefore, by disrupting microtubule assembly, Colchicine can functionally inhibit the cellular processes that rely on Liprin α2's regulatory function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that can disrupt the microtubule network. Since Liprin α2 is involved in the regulation of microtubule dynamics, Nocodazole can inhibit Liprin α2's function by altering the microtubule architecture, which is essential for its role in cellular processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly. By hyperstabilizing microtubules, Paclitaxel can inhibit the regulatory role of Liprin α2 in microtubule dynamics, which is critical for its involvement in neuronal function and organization. | ||||||