LIMK-2 Activators
LIMK-2 Activators belong to a chemical class of compounds that play a pivotal role in modulating the activity of the enzyme LIM domain kinase 2 (LIMK-2). LIMK-2 is a serine/threonine kinase that is involved in regulating the actin cytoskeleton, a dynamic network of protein filaments essential for various cellular processes, including cell motility, shape, and adhesion. LIMK-2 plays a critical role in phosphorylating and inactivating cofilin, an actin-binding protein that severs actin filaments, thereby influencing actin dynamics. LIMK-2 Activators are small molecules that interact with LIMK-2, leading to the activation of its kinase activity. This activation, in turn, promotes the phosphorylation and inactivation of cofilin, ultimately influencing actin filament stability and organization within the cell.
The modulation of LIMK-2 activity by LIMK-2 Activators is a key regulatory mechanism in the control of actin dynamics. Actin filaments are essential for processes such as cell migration, cell division, and the formation of cellular protrusions like filopodia and lamellipodia. By activating LIMK-2, these molecules impact the balance between actin polymerization and depolymerization, which is crucial for cell shape changes and motility. LIMK-2 Activators, by targeting this specific kinase, offer a means to study the intricate regulation of the actin cytoskeleton in various cellular contexts. Their use in research provides valuable insights into the underlying mechanisms governing cell morphology and motility.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of ROCK (Rho-associated protein kinase), which leads to the indirect activation of LIMK-2 by reducing inhibitory phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Activates EP receptors, which can lead to downstream activation of LIMK-2 through G-protein signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, potentially leading to increased cAMP and indirect activation of LIMK-2 through PKA-mediated pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Activates the insulin receptor, leading to downstream signaling cascades that might affect LIMK-2 activity. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $117.00 | 1 | |
While primarily an anticoagulant, heparin can influence cell signaling pathways that might affect LIMK-2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Known to affect GSK-3β activity, potentially influencing LIMK-2 function indirectly through Wnt signaling pathway modulation. | ||||||