Date published: 2025-10-26

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LIMK-1 Activators

LIM kinase 1 (LIMK-1) plays a pivotal role in regulating actin dynamics, contributing to cellular motility and morphology. The chemical activators of LIMK-1 operate through precise modulation of its downstream signaling pathways, orchestrating a complex dance of cytoskeletal rearrangements. BMS-5 and CK-869, as inhibitors of Rho-associated protein kinase (ROCK), activate LIMK-1 by unleashing its inhibitory influence on LIMK-1. This unleashing enhances LIMK-1 activity, promoting actin cytoskeleton remodeling and cellular motility. CK-666 and ML-141, inhibitors of the Arp2/3 complex, activate LIMK-1 by disrupting the balance between actin polymerization and depolymerization. This disruption enhances LIMK-1-mediated cofilin phosphorylation, leading to actin cytoskeleton rearrangement and increased cellular motility. Tanshinone IIA and C3 Transferase, by inhibiting RhoA, activate LIMK-1 and drive its downstream signaling cascade. RhoA inhibition enhances LIMK-1 activity, promoting cofilin phosphorylation and actin cytoskeleton dynamics. Jasplakinolide and Blebbistatin, through stabilization of F-actin and inhibition of myosin II, respectively, activate LIMK-1 by influencing actin dynamics. The stabilized F-actin or reduced myosin II activity amplifies LIMK-1-mediated cofilin phosphorylation, orchestrating cytoskeletal rearrangement.

Y-27632 and Fasudil, ROCK inhibitors, activate LIMK-1 by releasing its inhibitory constraints. This release enhances LIMK-1 activity, promoting actin cytoskeleton remodeling and cellular motility. CK-548 and SMIFH2, inhibitors of the Arp2/3 complex and formin-mediated actin polymerization, respectively, activate LIMK-1 by disrupting the delicate balance in actin dynamics. These disruptions amplify LIMK-1-mediated cofilin phosphorylation, leading to intricate changes in the actin cytoskeleton. In conclusion, the chemical class of LIMK-1 activators acts as sculptors, finely tuning the actin landscape to regulate cellular motility and morphology. Understanding the intricate interplay between these activators and LIMK-1 provides insights into the molecular mechanisms governing cytoskeletal dynamics, with potential implications in fields such as cell migration and tissue development.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

CK 666

442633-00-3sc-361151
sc-361151A
10 mg
50 mg
$315.00
$1020.00
5
(0)

CK-666 activates LIMK-1 by inhibiting Arp2/3 complex. Arp2/3 inhibition enhances LIMK-1-mediated cofilin phosphorylation, leading to actin cytoskeleton rearrangement.

Tanshinone IIA

568-72-9sc-200932
sc-200932A
5 mg
25 mg
$86.00
$310.00
22
(2)

Tanshinone IIA activates LIMK-1 by inhibiting RhoA. RhoA inhibition enhances LIMK-1 activity, promoting cofilin phosphorylation and actin cytoskeleton dynamics.

Jasplakinolide

102396-24-7sc-202191
sc-202191A
50 µg
100 µg
$180.00
$299.00
59
(1)

Jasplakinolide activates LIMK-1 by stabilizing F-actin. Increased F-actin stability enhances LIMK-1-mediated cofilin phosphorylation, leading to actin cytoskeleton rearrangement.

CK-869

388592-44-7sc-507274
5 mg
$160.00
(0)

CK-869 activates LIMK-1 by inhibiting ROCK. ROCK inhibition enhances LIMK-1 activity, promoting actin cytoskeleton remodeling and cellular motility.

ML 141

71203-35-5sc-362768
sc-362768A
5 mg
25 mg
$134.00
$502.00
7
(1)

ML-141 activates LIMK-1 by inhibiting Arp2/3 complex. Arp2/3 inhibition enhances LIMK-1-mediated cofilin phosphorylation, leading to actin cytoskeleton rearrangement.

(±)-Blebbistatin

674289-55-5sc-203532B
sc-203532
sc-203532A
sc-203532C
sc-203532D
5 mg
10 mg
25 mg
50 mg
100 mg
$179.00
$307.00
$455.00
$924.00
$1689.00
7
(1)

Blebbistatin activates LIMK-1 by inhibiting myosin II. Myosin II inhibition enhances LIMK-1-mediated cofilin phosphorylation, leading to actin cytoskeleton rearrangement.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

Y-27632 activates LIMK-1 by inhibiting ROCK. ROCK inhibition enhances LIMK-1 activity, promoting actin cytoskeleton remodeling and cellular motility.

SMIFH2

340316-62-3sc-507273
5 mg
$140.00
(0)

SMIFH2 activates LIMK-1 by disrupting formin-mediated actin polymerization. Disrupted polymerization enhances LIMK-1 activity, leading to actin cytoskeleton rearrangement.