LHX8 Inhibitors
LHX8 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the LHX8 protein, also known as LIM homeobox 8. LHX8 is a member of the LIM homeobox transcription factor family, which plays essential roles in regulating gene expression and developmental processes in various organisms. LHX8, in particular, has been associated with critical functions in organogenesis and tissue development during embryogenesis. Inhibitors designed to target LHX8 are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this transcription factor.
The development of LHX8 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with LHX8 and modulate its transcriptional activity. By inhibiting LHX8, these compounds can potentially disrupt its role in regulating gene expression patterns during development, affecting processes such as organ formation and tissue differentiation. Researchers use LHX8 inhibitors to explore the intricate roles played by this transcription factor in cellular functions, attempting to unravel its contributions to tissue-specific gene regulation, cellular differentiation, and embryonic development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine can cause hypomethylation of DNA, potentially leading to altered expression of genes including transcription factors. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit transcription by RNA polymerase II, which might reduce LHX8 expression as a downstream effect. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
As an HDAC inhibitor, Vorinostat may alter chromatin accessibility and indirectly downregulate transcription factor expression including LHX8. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294, a G9a histone methyltransferase inhibitor, may change histone methylation status and affect gene expression, including LHX8. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, a DNA methyltransferase inhibitor, could lead to decreased methylation and possibly lower transcription of certain genes. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to G-C rich DNA sequences, potentially inhibiting transcription factors like LHX8 that bind to similar regions in the genome. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate metal ions, potentially disrupting metalloprotein DNA binding activity and affecting transcription factor gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been found to modulate various signal transduction pathways, potentially influencing transcription factor activity and gene expression. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
By inhibiting histone methyltransferases, chaetocin can affect chromatin structure and potentially downregulate genes encoding transcription factors. | ||||||