LHX8 Activators
LHX8 Activators is a chemical class that has garnered significant attention in the field of molecular biology and genetics. These compounds are known for their unique ability to modulate the activity of the LHX8 gene, which encodes a transcription factor with critical roles in embryonic development, tissue differentiation, and cell fate determination. LHX8, short for LIM-Homeobox 8, belongs to the LIM-homeodomain family of transcription factors, characterized by the presence of two LIM domains and a homeodomain. Activators of LHX8 play a pivotal role in regulating the transcriptional machinery that governs the development of various tissues and organs in vertebrates.
Chemically, LHX8 activators are diverse, comprising both synthetic and naturally occurring compounds. These molecules function by binding to specific regulatory elements within the LHX8 gene promoter or enhancer regions, thereby modulating the rate of gene transcription. The activation of LHX8 can have profound effects on cellular differentiation processes, particularly in tissues such as the nervous system, pancreas, and heart.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP). cAMP can activate protein kinase A (PKA) and other downstream signaling pathways that may influence gene expression, potentially including LHX8. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase (HDAC) inhibitor. It can lead to histone hyperacetylation, which is associated with open chromatin and increased gene transcription. This process may indirectly enhance the activity of LHX8 or related pathways. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-dC is a DNA methyltransferase inhibitor. It can reduce DNA methylation, which can affect gene expression, particularly in genes that are silenced by DNA methylation. By demethylating DNA, it may indirectly promote the activity of genes like LHX8. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is also an HDAC inhibitor, similar to TSA. It can promote histone hyperacetylation, influence chromatin structure, and impact gene transcription. This effect may directly enhance the activity of genes like LHX8. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A and acts as a ligand for retinoic acid receptors (RARs). It can modulate gene expression by binding to RARs and regulating target genes, potentially increasing LHX8 through retinoic acid-responsive elements. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
TPA is a protein kinase C (PKC) activator. It can activate PKC-dependent signaling pathways, which may impact gene expression indirectly, potentially increasing LHX8. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is both an HDAC inhibitor and a GABAergic agent. It can affect histone acetylation and potentially activate gene expression directly, including genes like LHX8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural polyphenol with antioxidant and anti-inflammatory properties. Its modulation of various signaling pathways may indirectly impact gene expression, potentially increasing the activity of LHX8 or related pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is another natural polyphenol with antioxidant properties. It can activate certain signaling pathways and transcription factors that may influence gene expression indirectly, potentially increasing LHX8. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is a solvent commonly used to dissolve other compounds for research purposes. It may have indirect effects on gene expression through its influence on cellular processes, including increasing LHX8. | ||||||