LHFPL2 Inhibitors
Chemical inhibitors of LHFPL2 operate through various mechanisms that impact the protein's function within cellular membranes. Phloretin, a dihydrochalcone, is known to disrupt membrane dynamics by inhibiting glucose transporters, which may indirectly alter the tetraspan complex formation that LHFPL2 is a part of. The isoflavones Daidzein and Genistein engage with the lipid raft domains through their interference with the PI3K and tyrosine kinase pathways, respectively. The inhibition of these kinases can alter the signaling and localization of LHFPL2. Specifically, Genistein can disrupt cellular signaling pathways that are essential for the proper function of LHFPL2 within the membrane. Similarly, Quercetin's inhibition of phospholipase C (PLC) can lead to disruption of phosphatidylinositol signaling pathways, which are vital for LHFPL2's role in membrane protein signaling and may result in its functional inhibition.
Further, LY294002 and Wortmannin, as specific PI3K inhibitors, can modify membrane dynamics, which is critical for LHFPL2's activity, leading to its functional inhibition. PD98059, by targeting MEK in the MAPK/ERK pathway, can indirectly inhibit LHFPL2's function, as this pathway is integral to various cellular functions related to membrane protein regulation. U73122, another PLC inhibitor, can disrupt the inositol phosphate metabolism affecting LHFPL2's associated signaling pathways. Gö 6983 and Bisindolylmaleimide I, both of which are inhibitors of PKC, can alter the regulatory processes for membrane-associated proteins, thereby inhibiting LHFPL2's activity. Staurosporine, a broad-spectrum kinase inhibitor, and Chelerythrine, a PKC inhibitor, can also impact the membrane-associated signaling processes that LHFPL2 is involved in, leading to its functional inhibition by impairing the necessary signaling networks required for its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin, a dihydrochalcone found in apple leaves, is known to inhibit various glucose transporters. While LHFPL2 is not a glucose transporter, its tetraspan structure is a part of membrane-associated complexes. Inhibition of glucose transport can alter membrane dynamics, indirectly inhibiting LHFPL2's function within those complexes. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $25.00 $75.00 $150.00 | 32 | |
Daidzein, an isoflavone found in soybeans, is recognized for its ability to interfere with phosphoinositide 3-kinases (PI3K). LHFPL2, being associated with lipid raft domains, can be affected by alterations in PI3K activity, which is critical for membrane protein signaling and trafficking, leading to functional inhibition. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, another isoflavone similar to Daidzein, inhibits tyrosine kinases. By inhibiting tyrosine kinase activity, Genistein can disrupt signaling pathways that contribute to the proper localization and function of membrane proteins like LHFPL2, thereby functionally inhibiting its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that can inhibit phospholipase C (PLC). Given that PLC plays a role in modulating the phosphatidylinositol signaling pathway, which is important for membrane-associated proteins, Quercetin's action can lead to an indirect functional inhibition of LHFPL2 through altered membrane protein signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. By inhibiting PI3K, LY294002 can affect membrane dynamics and signal transduction pathways associated with membrane proteins, including LHFPL2, possibly leading to functional inhibition due to altered membrane-associated processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 specifically inhibits MEK, which is part of the MAPK/ERK pathway. The ERK pathway is implicated in the regulation of various cellular functions, including those related to membrane proteins. Inhibition of this pathway by PD98059 can therefore indirectly lead to functional inhibition of LHFPL2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. LHFPL2, being a membrane-associated protein, may rely on PI3K-dependent pathways for its localization and activity. Inhibition of PI3K by Wortmannin can thus lead to functional inhibition of LHFPL2 by altering the membrane dynamics and signaling. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a pan-PKC inhibitor that can disrupt protein kinase C (PKC)-dependent pathways. Since PKC is involved in the regulation of various cellular processes, including those related to membrane protein function, inhibiting PKC can indirectly lead to functional inhibition of LHFPL2. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. By inhibiting PKC, this compound can affect signaling pathways that involve membrane proteins. This inhibition can indirectly disrupt the functional activity of LHFPL2 by impairing the necessary signaling for its activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that, among other targets, inhibits PKC. Since PKC-mediated signaling is implicated in the regulation of membrane-associated proteins, Staurosporine's broad kinase inhibition can indirectly lead to functional inhibition of LHFPL2. | ||||||