Lex A Activators
The Lex A Activators class encompasses a diverse array of chemicals with the ability to either directly or indirectly activate Lex A, a crucial transcriptional regulator involved in the bacterial SOS response. These activators offer valuable insights into the intricate regulatory mechanisms governing Lex A-mediated cellular responses to DNA damage and stress. One notable member of this class is Allicin, a natural compound found in garlic. Allicin's ability to influence cellular redox status and promote oxidative stress positions it as a direct activator of Lex A. By creating an oxidative environment, Allicin may trigger the activation of Lex A, providing researchers with a pharmacological tool to probe the redox-mediated regulation of Lex A and its downstream effects.
Another intriguing activator is Quercetin, a flavonoid found in various fruits and vegetables. Quercetin's indirect activation of Lex A is attributed to its impact on cellular signaling pathways related to DNA damage repair, particularly the ATM/ATR pathway. This suggests a role for Quercetin in enhancing Lex A activity and unraveling the complexities of its involvement in cellular responses to genotoxic stress. Furthermore, Tocotrienols, members of the vitamin E family, represent indirect activators of Lex A by influencing cellular redox status. Their ability to modulate antioxidant pathways provides a pharmacological avenue to explore the interplay between redox regulation and Lex A-mediated cellular responses. Collectively, the Lex A Activators class offers a toolbox for researchers aiming to dissect the molecular mechanisms governing Lex A activation. These chemicals open avenues for understanding the intricate interplay between redox signaling, DNA damage repair pathways, and Lex A-mediated cellular stress responses, providing critical insights into bacterial adaptive strategies in the face of genotoxic challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allicin | 539-86-6 | sc-202449 sc-202449A | 1 mg 5 mg | $460.00 $1428.00 | 7 | |
Allicin potentially activates Lex A. Its precise mechanism involves influencing cellular redox status, promoting oxidative stress. This oxidative environment can trigger Lex A activation, possibly through the modulation of redox-sensitive regulatory elements. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid abundant in fruits and vegetables, may act as an indirect activator of Lex A. By influencing cellular signaling pathways related to DNA damage repair, such as the ATM/ATR pathway, Quercetin can potentially enhance Lex A activity. Its ability to modulate DNA repair pathways indirectly suggests a role in promoting Lex A-mediated cellular responses to genotoxic stress. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
Vitamin K3 may serve as a potential activator of Lex A. Its mechanism of action involves generating intracellular reactive oxygen species (ROS), leading to oxidative stress. The resulting oxidative environment could activate Lex A, possibly through redox-sensitive pathways. | ||||||
Juglone | 481-39-0 | sc-202675 sc-202675A | 1 g 5 g | $66.00 $222.00 | 6 | |
Juglone, a natural compound found in certain plants, could potentially activate Lex A through mechanisms related to oxidative stress. By inducing the generation of reactive oxygen species (ROS), Juglone may create an oxidative environment that triggers Lex A activation. Its ability to modulate redox-sensitive pathways suggests its potential as a pharmacological tool for exploring the interplay between oxidative stress and Lex A-mediated cellular responses. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic Acid, a polyphenolic compound found in various fruits and nuts, may act as an indirect activator of Lex A. Its mechanism involves influencing cellular signaling pathways related to DNA damage repair, possibly through interactions with the ATM/ATR pathway. Ellagic Acid's capacity to modulate DNA repair pathways suggests its potential in enhancing Lex A activity and understanding its role in cellular responses to genotoxic stress. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, may act as an indirect activator of Lex A by influencing cellular signaling pathways related to DNA damage repair, such as the ATM/ATR pathway. Its ability to modulate these pathways suggests a potential role in enhancing Lex A activity and understanding its contribution to cellular responses to genotoxic stress. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-Lipoic Acid, a coenzyme involved in mitochondrial function, may act as an indirect activator of Lex A. Its mechanism involves influencing cellular redox status, potentially through interactions with antioxidant pathways. By promoting a redox environment, Alpha-Lipoic Acid could enhance Lex A activity, providing a pharmacological approach to investigate the interplay between redox regulation and Lex A-mediated cellular responses. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, a natural triterpenoid, may act as a potential activator of Lex A. Its mechanism involves influencing cellular redox status, possibly through interactions with antioxidant pathways. By modulating redox-sensitive elements, Betulinic Acid could activate Lex A, offering a pharmacological tool to explore the redox regulation of Lex A and its implications in cellular stress responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, may act as an indirect activator of Lex A. Its mechanism involves the activation of cellular antioxidant pathways, potentially leading to modulation of redox status. By promoting an antioxidant environment, Sulforaphane could enhance Lex A activity, offering a pharmacological approach to investigate the interplay between antioxidant pathways and Lex A-mediated cellular responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major polyphenol in green tea, may act as an indirect activator of Lex A. Its mechanism involves influencing cellular signaling pathways related to DNA damage repair, possibly through interactions with the ATM/ATR pathway. EGCG's capacity to modulate DNA repair pathways suggests its potential in enhancing Lex A activity and understanding its role in cellular responses to genotoxic stress. | ||||||