Lex A Inhibitors
The Lex A Inhibitors class comprises a diverse set of compounds that can either directly or indirectly modulate the activity of Lex A, a key transcriptional repressor involved in the bacterial SOS response. These inhibitors offer pharmacological strategies for controlling Lex A-mediated cellular responses. Certain compounds within this class, such as Novobiocin, Ciprofloxacin, Trimethoprim, Nalidixic Acid, and Moxifloxacin, indirectly inhibit Lex A by targeting bacterial DNA gyrase. These compounds disrupt DNA replication and repair processes, indirectly modulating Lex A activity and offering pharmacological approaches for influencing Lex A-mediated cellular responses through the modulation of DNA gyrase.
Additionally, Methyl methanesulfonate (MMS), Mitomycin C, 4-Nitroquinoline 1-Oxide (4-NQO), Rifampicin, Hydroxyurea, and 5-Fluorouracil (5-FU) directly influence Lex A through distinct mechanisms. MMS induces DNA damage, leading to the cleavage and inactivation of Lex A, while Mitomycin C and 4-NQO form DNA cross-links, activating the SOS response. Rifampicin indirectly modulates Lex A by affecting bacterial RNA synthesis, and Hydroxyurea depletes cellular dNTP pools, indirectly influencing Lex A. 5-FU interferes with bacterial thymidine biosynthesis, indirectly modulating Lex A activity. These direct and indirect inhibitory mechanisms highlight the intricate regulatory networks governing Lex A and provide a foundation for further exploration of their precise roles in bacterial DNA damage response. The Lex A Inhibitors class thus represents a valuable toolkit for researchers investigating the modulation of Lex A and its associated cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $96.00 $355.00 | ||
Novobiocin is a gyrase inhibitor that indirectly inhibits Lex A. By targeting bacterial DNA gyrase, Novobiocin disrupts DNA replication and repair processes, indirectly modulating Lex A activity. This indirect inhibition highlights the interconnectedness of DNA gyrase function and Lex A regulation, providing a potential pharmacological approach to influence Lex A-mediated cellular responses. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
Methyl methanesulfonate (MMS) is a DNA alkylating agent that directly influences Lex A. By inducing DNA damage, MMS activates the SOS response, leading to the cleavage and inactivation of Lex A. This direct inhibition underscores the role of DNA damage in regulating Lex A and offers a specific pharmacological approach for modulating Lex A-mediated cellular responses through targeted induction of DNA lesions. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $42.00 | 8 | |
Ciprofloxacin is a fluoroquinolone antibiotic that indirectly inhibits Lex A. By targeting bacterial DNA gyrase, Ciprofloxacin disrupts DNA replication and repair processes, indirectly modulating Lex A activity. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is an antitumor antibiotic that directly influences Lex A. By forming DNA cross-links, Mitomycin C activates the SOS response, leading to the cleavage and inactivation of Lex A. This direct inhibition underscores the role of DNA cross-linking in regulating Lex A and offers a specific pharmacological approach for modulating Lex A-mediated cellular responses through targeted DNA damage induction. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $66.00 $158.00 $204.00 $707.00 $3334.00 | 4 | |
Trimethoprim is a dihydrofolate reductase inhibitor that indirectly inhibits Lex A. By interfering with bacterial folate metabolism, Trimethoprim disrupts DNA synthesis and repair processes, indirectly modulating Lex A activity. This indirect inhibition highlights the connection between folate metabolism and Lex A regulation, providing a potential pharmacological approach to influence Lex A-mediated cellular responses. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea is a ribonucleotide reductase inhibitor that indirectly influences Lex A. By depleting cellular dNTP pools, Hydroxyurea disrupts DNA synthesis and repair processes, indirectly modulating Lex A activity. This indirect inhibition highlights the connection between dNTP availability and Lex A regulation, providing a potential pharmacological approach to influence Lex A-mediated cellular responses. | ||||||
4-Nitroquinoline N-oxide | 56-57-5 | sc-256815 sc-256815A | 1 g 5 g | $122.00 $413.00 | 6 | |
4-Nitroquinoline N-oxide (4-NQO) is a DNA-damaging agent that directly influences Lex A. By inducing DNA lesions, 4-NQO activates the SOS response, leading to the cleavage and inactivation of Lex A. This direct inhibition underscores the role of DNA damage in regulating Lex A and offers a specific pharmacological approach for modulating Lex A-mediated cellular responses through targeted induction of DNA lesions. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin is an RNA polymerase inhibitor that indirectly inhibits Lex A. By affecting bacterial RNA synthesis, Rifampicin disrupts the transcriptional regulation of Lex A, indirectly modulating its activity. This indirect inhibition highlights the connection between RNA polymerase activity and Lex A regulation, providing a potential pharmacological approach to influence Lex A-mediated cellular responses. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is a thymidylate synthase inhibitor that indirectly influences Lex A. By interfering with bacterial thymidine biosynthesis, 5-FU disrupts DNA synthesis and repair processes, indirectly modulating Lex A activity. This indirect inhibition highlights the connection between thymidylate synthase function and Lex A regulation, providing a potential pharmacological approach to influence Lex A-mediated cellular responses. | ||||||
Acriflavine | 8048-52-0 | sc-214489 sc-214489A | 25 g 100 g | $49.00 $168.00 | 2 | |
Acriflavine is a DNA-intercalating agent that directly influences Lex A. By binding to DNA, Acriflavine activates the SOS response, leading to the cleavage and inactivation of Lex A. This direct inhibition underscores the role of DNA intercalation in regulating Lex A and offers a specific pharmacological approach for modulating Lex A-mediated cellular responses through targeted interaction with DNA. | ||||||