Date published: 2025-9-11

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LEREPO4 Activators

Chemical activators of LEREPO4 include a variety of compounds that influence different biochemical pathways leading to the activation of this protein. Forskolin is known for its ability to activate adenylate cyclase, which subsequently increases the levels of cAMP within the cell. The rise in cAMP levels can activate protein kinase A (PKA). PKA then has the capability to phosphorylate various proteins, including LEREPO4, which results in its activation. Similarly, dibutyryl-cAMP, a synthetic analog of cAMP, can permeate cellular membranes and engage PKA in the phosphorylation of target proteins such as LEREPO4. Another chemical, Phorbol 12-myristate 13-acetate (PMA), activates protein kinase C (PKC), a kinase that phosphorylates a wide array of cellular proteins. The phosphorylation activity of PKC can lead to the activation of LEREPO4.

Ionomycin, by increasing intracellular calcium levels, can activate calmodulin-dependent kinases, which are capable of phosphorylating LEREPO4, thereby activating it. Glutamate, by binding to its receptors, can trigger a calcium influx, which also activates kinases that can then target LEREPO4 for activation. Epidermal Growth Factor (EGF) activates its receptor, leading to a signaling cascade that activates the MAPK/ERK pathway. The activated ERK may phosphorylate LEREPO4, leading to its activation. Insulin interacts with its receptor to start a cascade that activates the PI3K/Akt pathway, which includes a variety of proteins that can phosphorylate and activate LEREPO4. Hydrogen Peroxide serves as a signaling molecule, influencing redox-sensitive kinases that may directly phosphorylate LEREPO4. Lithium Chloride, by inhibiting GSK-3β, can lead to the activation of proteins that engage in signaling resulting in the phosphorylation and activation of LEREPO4. Okadaic Acid and Calyculin A, as inhibitors of protein phosphatases, lead to an overall increase in the phosphorylation state of proteins, which may include LEREPO4, resulting in its activation. Lastly, Anisomycin, which activates stress-activated protein kinases such as JNK, could lead to the activation of LEREPO4 through phosphorylation events initiated by these kinases.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin directly activates the enzyme adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate PKA, which, in turn, can phosphorylate and activate LEREPO4 as part of its signaling.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin acts as a calcium ionophore, elevating intracellular calcium levels. Increased calcium can activate calmodulin-dependent kinases, which may phosphorylate and thus activate LEREPO4.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC), which is known to phosphorylate a wide range of target proteins. PKC-mediated phosphorylation can lead to the activation of LEREPO4.

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$45.00
$130.00
$480.00
$4450.00
74
(7)

db-cAMP is a membrane-permeable cAMP analog that activates PKA. PKA then can phosphorylate target proteins, potentially including LEREPO4, leading to its activation.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin binds to its receptor, triggering a signaling cascade that activates PI3K/Akt pathway. Akt can phosphorylate numerous proteins, which may include LEREPO4, resulting in its activation.

L-Glutamic Acid

56-86-0sc-394004
sc-394004A
10 g
100 g
$291.00
$566.00
(0)

Glutamate binds to its receptors, leading to the activation of intracellular signaling pathways that can include calcium influx. Calcium-dependent kinases activated as a result can then activate LEREPO4.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

Hydrogen Peroxide can act as a signaling molecule, affecting redox-sensitive kinases that may phosphorylate and activate LEREPO4 directly.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium Chloride inhibits GSK-3β, which can lead to the activation of downstream proteins like β-catenin. β-catenin can engage in signaling pathways that result in the activation of LEREPO4.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Okadaic Acid is an inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins, which could include LEREPO4, thereby activating it.

Calyculin A

101932-71-2sc-24000
sc-24000A
sc-24000B
sc-24000C
10 µg
100 µg
500 µg
1 mg
$160.00
$750.00
$1400.00
$3000.00
59
(3)

Similar to Okadaic Acid, Calyculin A inhibits protein phosphatases, resulting in increased phosphorylation and potential activation of LEREPO4.