Chemical activators of LEREPO4 include a variety of compounds that influence different biochemical pathways leading to the activation of this protein. Forskolin is known for its ability to activate adenylate cyclase, which subsequently increases the levels of cAMP within the cell. The rise in cAMP levels can activate protein kinase A (PKA). PKA then has the capability to phosphorylate various proteins, including LEREPO4, which results in its activation. Similarly, dibutyryl-cAMP, a synthetic analog of cAMP, can permeate cellular membranes and engage PKA in the phosphorylation of target proteins such as LEREPO4. Another chemical, Phorbol 12-myristate 13-acetate (PMA), activates protein kinase C (PKC), a kinase that phosphorylates a wide array of cellular proteins. The phosphorylation activity of PKC can lead to the activation of LEREPO4.
Ionomycin, by increasing intracellular calcium levels, can activate calmodulin-dependent kinases, which are capable of phosphorylating LEREPO4, thereby activating it. Glutamate, by binding to its receptors, can trigger a calcium influx, which also activates kinases that can then target LEREPO4 for activation. Epidermal Growth Factor (EGF) activates its receptor, leading to a signaling cascade that activates the MAPK/ERK pathway. The activated ERK may phosphorylate LEREPO4, leading to its activation. Insulin interacts with its receptor to start a cascade that activates the PI3K/Akt pathway, which includes a variety of proteins that can phosphorylate and activate LEREPO4. Hydrogen Peroxide serves as a signaling molecule, influencing redox-sensitive kinases that may directly phosphorylate LEREPO4. Lithium Chloride, by inhibiting GSK-3β, can lead to the activation of proteins that engage in signaling resulting in the phosphorylation and activation of LEREPO4. Okadaic Acid and Calyculin A, as inhibitors of protein phosphatases, lead to an overall increase in the phosphorylation state of proteins, which may include LEREPO4, resulting in its activation. Lastly, Anisomycin, which activates stress-activated protein kinases such as JNK, could lead to the activation of LEREPO4 through phosphorylation events initiated by these kinases.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates the enzyme adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate PKA, which, in turn, can phosphorylate and activate LEREPO4 as part of its signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, elevating intracellular calcium levels. Increased calcium can activate calmodulin-dependent kinases, which may phosphorylate and thus activate LEREPO4. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a wide range of target proteins. PKC-mediated phosphorylation can lead to the activation of LEREPO4. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a membrane-permeable cAMP analog that activates PKA. PKA then can phosphorylate target proteins, potentially including LEREPO4, leading to its activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin binds to its receptor, triggering a signaling cascade that activates PI3K/Akt pathway. Akt can phosphorylate numerous proteins, which may include LEREPO4, resulting in its activation. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate binds to its receptors, leading to the activation of intracellular signaling pathways that can include calcium influx. Calcium-dependent kinases activated as a result can then activate LEREPO4. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide can act as a signaling molecule, affecting redox-sensitive kinases that may phosphorylate and activate LEREPO4 directly. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, which can lead to the activation of downstream proteins like β-catenin. β-catenin can engage in signaling pathways that result in the activation of LEREPO4. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins, which could include LEREPO4, thereby activating it. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits protein phosphatases, resulting in increased phosphorylation and potential activation of LEREPO4. |