Laminin β-3 Activators
Laminin β-3 Activators are a group of chemical compounds which have distinct biochemical or cellular influences that could lead to the functional activation of Laminin β-3. These compounds are capable of enhancing the function of Laminin β-3 primarily through the upregulation of integrin expression. For example, Retinoic Acid, an active metabolite of Vitamin A, increases the expression of integrins, which are primary receptors for Laminin β-3. Similarly, DHA, an omega-3 fatty acid, Resveratrol, Nicotinamide, and Ascorbic Acid, also promote integrin expression, thus indirectly enhancing Laminin β-3 function.
Other compounds like Epidermal Growth Factor (EGF), Forskolin, Prostaglandin E2 (PGE2), Sphingosine-1-Phosphate (S1P), and Curcumin, act via different pathways but ultimately enhance the function of Laminin β-3 by interacting with its receptor complex or signaling pathways. EGF, for instance, enhances Laminin β-3 function by activating the PI3K/Akt pathway via EGFR. Forskolin and PGE2, on the other hand, increase cAMP levels, thereby upregulating integrin receptors. S1P and Curcumin have complex cellular targets, but their ultimate effect leads to the functional activation of Laminin β-3. In the case of S1P, it binds to its receptor (S1PR1-5), leading to activation of downstream pathways such as PI3K/Akt, which interacts with Laminin β-3. Similarly, Curcumin influences NF-κB, a regulator of integrin expression, thereby enhancing the functionality of Laminin β-3. In conclusion, these Laminin β-3 Activators, through their distinct biochemical or cellular influences, are capable of enhancing the function of Laminin β-3 by interacting with its receptor complex or signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, an active metabolite of Vitamin A, plays a role in cellular differentiation and proliferation. It enhances the function of Laminin β-3 by increasing the expression of integrins, which are primary receptors for Laminin β-3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, resulting in increased levels of cyclic adenosine monophosphate (cAMP). cAMP indirectly enhances Laminin β-3 function by upregulating integrin receptors. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2, a potent inflammatory mediator, binds to its receptor (EP2/EP4), leading to increased cAMP levels. This, in turn, upregulates integrin expression, thus enhancing Laminin β-3 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid mediator that binds to its receptor (S1PR1-5), leading to activation of downstream pathways such as PI3K/Akt, which interacts with Laminin β-3. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA, an omega-3 fatty acid, has been shown to increase the expression of integrins, thereby enhancing the activity of Laminin β-3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates Sirtuin 1 (SIRT1), which has been shown to upregulate the expression of integrins, thus enhancing Laminin β-3 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has multiple cellular targets, including NF-κB, which is known to regulate the expression of integrins, thereby enhancing the functionality of Laminin β-3. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a form of Vitamin B3 that has been shown to enhance integrin expression, thus indirectly enhancing Laminin β-3 function. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic Acid is essential for collagen synthesis and can indirectly enhance Laminin β-3 function by promoting integrin expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, a process critical for the proper folding and function of many proteins. This can indirectly enhance Laminin β-3 function by promoting the expression of properly folded integrins. | ||||||