Laminin α-4 Inhibitors
Laminin α-4 inhibitors encompass a diverse array of chemicals that exert their influence either directly or indirectly on the activity of Laminin α-4, a protein crucial for cellular adhesion and migration. Among these, tyrosine kinase inhibitors like Nilotinib and Axitinib stand out as direct inhibitors. Nilotinib disrupts the ABL kinase pathway, indirectly modulating Laminin α-4 through integrin-mediated signaling, while Axitinib, a VEGFR inhibitor, impacts Laminin α-4 via integrin-VEGFR interactions. Indirect inhibitors include Brefeldin A, disrupting protein transport and affecting Laminin α-4 secretion, and Wortmannin, a PI3K inhibitor altering cell survival signaling pathways.
Several inhibitors target key cellular signaling pathways, showcasing their indirect impact on Laminin α-4. SB203580 and PD98059, MEK inhibitors, disrupt the MAPK pathway, influencing Laminin α-4 downstream targets and cellular processes. LY294002, a PI3K inhibitor, modulates Laminin α-4 indirectly through the PI3K/Akt pathway. Additionally, Rapamycin, a mTOR inhibitor, alters protein synthesis, affecting Laminin α-4 activity in processes related to cell proliferation and adhesion. SP600125, a JNK inhibitor, influences Laminin α-4 through the JNK pathway, impacting cellular processes like adhesion and migration. AMPK activator A769662 indirectly modulates Laminin α-4 by affecting energy regulation, showcasing the diversity of pathways involved in its modulation. Moreover, selective TGF-β receptor inhibitor SB431542 indirectly influences Laminin α-4, disrupting TGF-β signaling and altering downstream effectors. Collectively, these inhibitors provide a nuanced understanding of the intricate regulatory networks that govern Laminin α-4 function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Nilotinib, a tyrosine kinase inhibitor, directly influences the ABL kinase pathway. Laminin α-4, through integrin signaling, interacts with focal adhesion kinase (FAK). Nilotinib inhibits ABL, disrupting the downstream FAK signaling and indirectly modulating Laminin α-4 activity by altering integrin-mediated cellular adhesion and migration. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport from the endoplasmic reticulum to the Golgi apparatus. Laminin α-4, involved in cellular migration, is affected as its proper secretion and trafficking are hindered. This indirect inhibition occurs through interference with vesicular transport, leading to altered localization of Laminin α-4 and subsequent modulation of migratory processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor, impacting the MAPK pathway. Laminin α-4, regulated by MAPK signaling, experiences indirect modulation as SB203580 alters downstream effectors, such as ATF-2. This influences cell migration and adhesion processes, providing an indirect route for inhibiting Laminin α-4 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor affecting the PI3K/Akt pathway. Laminin α-4, involved in cell survival signaling, is indirectly inhibited by Wortmannin as it disrupts the PI3K pathway. This interference alters downstream signals, leading to modulation of Laminin α-4 function in cell survival and potentially affecting its role in tumor invasion. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, impacting protein synthesis and cell proliferation. Laminin α-4, influenced by mTOR signaling, undergoes indirect modulation. Rapamycin-mediated inhibition of mTOR alters the translation of proteins involved in cell adhesion, affecting Laminin α-4 activity and potentially impeding processes related to cell migration and tissue remodeling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, influencing the PI3K/Akt pathway. Laminin α-4, regulated by PI3K signaling, is indirectly modulated by LY294002. This inhibitor disrupts the PI3K pathway, altering downstream signals that impact Laminin α-4 function in cellular processes, such as adhesion and migration, providing an indirect route for inhibiting its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor affecting the JNK pathway. Laminin α-4, modulated by JNK signaling, undergoes indirect modulation through SP600125. This inhibitor disrupts the JNK pathway, influencing downstream targets like c-Jun, leading to altered Laminin α-4 activity and potential modulation of cellular processes associated with cell migration and tissue development. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator. Laminin α-4, associated with energy regulation, is indirectly modulated as A769662 activates AMPK. This leads to downstream effects on AMPK targets, influencing Laminin α-4 activity in cellular processes related to energy homeostasis, adhesion, and migration, providing an indirect mechanism for inhibiting its function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a selective inhibitor of TGF-β type I receptor, influencing the TGF-β signaling pathway. Laminin α-4, affected by TGF-β, undergoes indirect modulation by SB431542. This inhibitor disrupts TGF-β signaling, altering downstream effectors and potentially impacting Laminin α-4 activity in processes related to cell adhesion and migration, providing an indirect route for inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor impacting the MAPK pathway. Laminin α-4, regulated by MAPK signaling, is indirectly modulated by PD98059. This inhibitor disrupts the MAPK pathway, altering downstream targets and leading to altered Laminin α-4 activity, potentially influencing cellular processes like adhesion and migration, providing an indirect route for inhibiting its function. | ||||||