L-Alkaline phosphatase Inhibitors
L-Alkaline phosphatase inhibitors are a class of chemical compounds that specifically target and inhibit the enzymatic activity of L-alkaline phosphatase (L-ALP). Alkaline phosphatases (APs) are a group of hydrolase enzymes found throughout various organisms and tissues, responsible for dephosphorylating molecules such as nucleotides, proteins, and alkaloids under alkaline conditions. L-ALP, as a subset of these enzymes, plays a critical role in modulating cellular functions through its ability to remove phosphate groups from various substrates. This class of enzymes is dependent on metal ions like magnesium and zinc for activity, and their inhibition leads to a disruption in the enzymatic hydrolysis of phosphomonoesters. By blocking L-ALP's action, inhibitors alter phosphate metabolism and signaling pathways that are crucial to numerous physiological processes, such as energy transfer and regulation of molecular stability.
The inhibition of L-alkaline phosphatase is often achieved through structural analogs that mimic the enzyme's natural substrates, metal ion chelators that disrupt the active site, or molecules that bind competitively to the catalytic region, preventing substrate access. These inhibitors are essential tools in studying the enzymatic mechanisms of L-ALP and understanding the broader roles of phosphate in biochemical reactions. By influencing the enzyme's function, L-ALP inhibitors are instrumental in research related to enzyme kinetics, the structural elucidation of APs, and in exploring their contributions to cellular processes. The ongoing exploration of these inhibitors provides valuable insight into how enzymes interact with substrates at the molecular level, contributing to a broader understanding of phosphate management within biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into the genome, 5-Azacytidine can cause a reduction in the methylation status of gene promoters, potentially leading to the downregulation of L-Alkaline phosphatase gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can activate retinoic acid receptors that bind to DNA response elements, potentially decreasing transcription of the L-Alkaline phosphatase gene by altering promoter accessibility. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A may competitively bind to DNA at GC-rich sequences, potentially displacing transcription factors essential for the initiation of L-Alkaline phosphatase transcription, thus decreasing its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A can inhibit histone deacetylases, leading to hyperacetylation of histones, which could result in condensed chromatin and a subsequent decrease in L-Alkaline phosphatase gene expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide blocks peptide elongation during translation, which could lead to a general decrease in protein synthesis including that of L-Alkaline phosphatase. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is crucial for cell growth and protein synthesis; suppression of this pathway could lead to decreased synthesis of L-Alkaline phosphatase. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds tightly to DNA, obstructing the elongation phase of RNA synthesis, which could lead to reduced transcription and subsequent lower levels of L-Alkaline phosphatase. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $182.00 $661.00 | 10 | |
Chetomin disrupts HIF-pathway interactions, which could lead to the transcriptional silencing of certain hypoxia-inducible genes, potentially including those encoding L-Alkaline phosphatase under hypoxic conditions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, could enhance histone acetylation, potentially resulting in repressed transcription of genes including that for L-Alkaline phosphatase. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Fostriecin can selectively inhibit certain phosphatases, which may indirectly lead to the downregulation of the L-Alkaline phosphatase gene by altering the phosphorylation state of transcription factors. | ||||||