Kruppel Activators
Kruppel activators comprise a diverse group of chemical compounds that, through various cellular mechanisms, facilitate the functional activity of the Kruppel transcription factor. Forskolin, by increasing intracellular cAMP, indirectly enhances Kruppel's role in generegulation by activating PKA, which may phosphorylate and thus, promote Kruppel's DNA binding and transcriptional activity. Similarly, PMA acts as a PKC activator, enhancing Kruppel activity through phosphorylation modifications that could improve its interaction with genomic DNA or other regulatory proteins. Ionomycin, through elevation of intracellular calcium levels, could activate calcium-dependent kinases, which in turn might phosphorylate and enhance the activity of Kruppel. Complexes involving Kruppel may also be stabilized by EGCG, which inhibits competitive kinase signaling, thereby reducing inhibitory phosphorylation and enhancing Kruppel's function in gene regulation.
Compounds such as LY294002 and PD98059, by inhibiting PI3K and MEK respectively, may relieve Kruppel from negative regulation, thus indirectly increasing its transcriptional activity. The action of SB203580 and U0126, which inhibit p38 MAPK and MEK1/2, could similarly skew signaling towards a state that favors Kruppel activation, by reducing inhibitory phosphorylations that would otherwise dampen its activity. The biochemical landscape for Kruppel activation is further diversified by A23187, which increases intracellular calcium and can therefore activate calcium-dependent signaling pathways that positively influence Kruppel's activity. Staurosporine, despite its broad kinase inhibition profile, may preferentially enhance Kruppel by blocking specific kinases that negatively regulate it. Lastly, db-cAMP, as a cAMP analog, stimulates PKA, potentially augmenting Kruppel activity through phosphorylation that promotes nuclear localization and DNA-binding efficiency, hereby ensuring that Kruppel operates at an optimal level to regulate gene expression.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylyl cyclase activator, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate transcription factors including Kruppel, potentially enhancing its DNA binding activity and functional role in regulating gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent PKC activator. PKC can modulate transcription factors through phosphorylation. Since PKC signaling affects a wide range of transcriptional regulators, it may enhance the functional activity of Kruppel by modifying its interaction with other proteins or its DNA binding efficiency. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which activates calcium-signaling pathways. These pathways can influence the activity of transcription factors like Kruppel by altering their phosphorylation state or the composition of transcriptional complexes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that could potentially affect signaling pathways that regulate transcription factors. By inhibiting competitive kinase signaling, EGCG may indirectly enhance Kruppel activity by reducing inhibitory phosphorylation events. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate is a bioactive lipid that acts through G protein-coupled receptors to modulate cellular signaling pathways. This modulation can lead to changes in transcription factor activity, potentially enhancing Kruppel function in gene regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that shifts cellular signaling equilibria. By inhibiting PI3K, downstream signaling that may suppress transcription factors like Kruppel is reduced, possibly enhancing its activity by reducing negative regulatory inputs. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor that can alter MAPK pathway signaling. This alteration might lead to an enhanced activity of Kruppel if MAPK signaling exerts inhibitory control over transcriptional regulators that interact with or modify Kruppel. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor that could shift the signaling balance towards pathways that activate or enhance transcription factor function. Kruppel activity could be indirectly enhanced by the reduction of p38 MAPK-mediated inhibitory phosphorylations. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, potentially enhancing the activity of Kruppel by activating calcium-dependent protein kinases that positively regulate Kruppel's function in gene expression control. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. It could lead to the selective enhancement of Kruppel activity by inhibiting kinases that negatively regulate Kruppel, allowing for a more active state of this transcription factor. | ||||||